ADAMTS5 is a critical regulator of virus-specific T cell immunity McMahon, Meagan, Ye, Siying, Izzard, Leonard, Dlugolenski, Daniel, Tripp, Ralph A., Bean, Andrew G. D., McCulloch, Daniel R. and Stambas, John 2016, ADAMTS5 is a critical regulator of virus-specific T cell immunity, PLoS biology, vol. 14, no. 11, Article number : e1002580, pp. 1-22, doi: 10.1371/journal.pbio.1002580. Attached Files Name Description MIMEType Size Downloads mcmahon-adamts5-2016.pdf Published version application/pdf 3.08MB 5 Title ADAMTS5 is a critical regulator of virus-specific T cell immunity Author(s) McMahon, Meagan Ye, Siying Izzard, Leonard Dlugolenski, Daniel Tripp, Ralph A. Bean, Andrew G. D. McCulloch, Daniel R. Stambas, John orcid.org/0000-0002-5690-2551 Journal name PLoS biology Volume number 14 Issue number 11 Season Article number : e1002580 Start page 1 End page 22 Total pages 22 Publisher PLoS Place of publication San Francisco, Calif. Publication date 2016-11-17 ISSN 1544-9173 1545-7885 Summary The extracellular matrix (ECM) provides physical scaffolding for cellular constituents and initiates biochemical and biomechanical cues that are required for physiological activity of living tissues. The ECM enzyme ADAMTS5, a member of the ADAMTS (A Disintegrin-like and Metalloproteinase with Thrombospondin-1 motifs) protein family, cleaves large proteoglycans such as aggrecan, leading to the destruction of cartilage and osteoarthritis. However, its contribution to viral pathogenesis and immunity is currently undefined. Here, we use a combination of in vitro and in vivo models to show that ADAMTS5 enzymatic activity plays a key role in the development of influenza-specific immunity. Influenza virus infection of Adamts5-/- mice resulted in delayed virus clearance, compromised T cell migration and immunity and accumulation of versican, an ADAMTS5 proteoglycan substrate. Our research emphasises the importance of ADAMTS5 expression in the control of influenza virus infection and highlights the potential for development of ADAMTS5-based therapeutic strategies to reduce morbidity and mortality. Language eng DOI 10.1371/journal.pbio.1002580 Field of Research 110799 Immunology not elsewhere classified Socio Economic Objective 920109 Infectious Diseases HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30091438 Document type: Journal Article Collections: School of Medicine Open Access Collection Related Links Link Description Connect to Elements publication management system Go to link with your DU access privileges   Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Wed, 22 Feb 2017, 15:36:53 EST Thu, 23 Feb 2017, 04:00:23 EST Fri, 24 Feb 2017, 07:23:47 EST Sat, 25 Feb 2017, 05:07:12 EST Fri, 03 Mar 2017, 10:53:58 EST Fri, 03 Mar 2017, 11:01:40 EST Mon, 06 Mar 2017, 09:06:42 EST Filtered Full Citation counts:   Cited 2 times in TR Web of Science Cited 2 times in Scopus Search Google Scholar Access Statistics: 47 Abstract Views, 5 File Downloads  -  Detailed Statistics Created: Wed, 22 Feb 2017, 15:36:53 EST

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