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Participant characteristics as modifiers of response to N-Acetyl cysteine (NAC) in obsessive-compulsive disorder

Sarris, Jerome, Oliver, Georgina, Camfield, David A. and Dean, Olivia M. 2016, Participant characteristics as modifiers of response to N-Acetyl cysteine (NAC) in obsessive-compulsive disorder, Clinical psychological science, vol. 4, no. 6, pp. 1104-1111, doi: 10.1177/2167702616639864.

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Title Participant characteristics as modifiers of response to N-Acetyl cysteine (NAC) in obsessive-compulsive disorder
Author(s) Sarris, Jerome
Oliver, Georgina
Camfield, David A.
Dean, Olivia M.ORCID iD for Dean, Olivia M. orcid.org/0000-0002-2776-3935
Journal name Clinical psychological science
Volume number 4
Issue number 6
Start page 1104
End page 1111
Total pages 8
Publisher Sage Publications
Place of publication London, Eng.
Publication date 2016
ISSN 2167-7026
2167-7034
Keyword(s) NAC
OCD
nutraceutical
clinical trial
moderators
Summary We previously reported on a 16-week, double-blind, randomized placebo-controlled trial (RCT) using 3 grams per day of N-acetyl cysteine (NAC) (1.5 grams twice per day) in 44 participants (aged 18–70) with DSM-5-diagnosed obsessive-compulsive disorder (OCD). We now report on an analysis of age, severity and duration of illness, OCD presentation type, baseline anxiety and depression scores, as well as the use of antidepressant medications as potentially modifying factors. Results revealed a significant effect (p =.037) for younger participants (under mean age of 34) responding to NAC. This remained significant using OCD severity as a covariate (p =.044). For those under 34 years of age with less than 17 years of OCD duration, this was also significant (p =.037). Regression analysis within the NAC treatment group also revealed that duration of OCD presentation was a significant predictor of Yale-Brown Obsessive Compulsive Scale (YBOCS) change at study endpoint (p =.019), whereas baseline Montgomery–Asberg Depression Rating Scale scores were also a trend-level predictor (p =.060) of YBOCS change in the NAC group.
Language eng
DOI 10.1177/2167702616639864
Field of Research 110999 Neurosciences not elsewhere classified
Socio Economic Objective 920111 Nervous System and Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091506

Document type: Journal Article
Collection: School of Medicine
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