Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis

Chatterton, Mary Lou, Stockings, Emily, Berk, Michael, Barendregt, Jan J., Carter, Rob and Mihalopoulos, Cathrine 2017, Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis, British journal of psychiatry, vol. 210, no. 5, pp. 333-341, doi: 10.1192/bjp.bp.116.195321.

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Title Psychosocial therapies for the adjunctive treatment of bipolar disorder in adults: network meta-analysis
Author(s) Chatterton, Mary LouORCID iD for Chatterton, Mary Lou
Stockings, Emily
Berk, MichaelORCID iD for Berk, Michael
Barendregt, Jan J.
Carter, RobORCID iD for Carter, Rob
Mihalopoulos, CathrineORCID iD for Mihalopoulos, Cathrine
Journal name British journal of psychiatry
Volume number 210
Issue number 5
Start page 333
End page 341
Total pages 9
Publisher Royal College of Psychiatrists
Place of publication London, Eng.
Publication date 2017-05
ISSN 1472-1465
Summary BackgroundFew trials have compared psychosocial therapies for people with bipolar affective disorder, and conventional meta-analyses provided limited comparisons between therapies.AimsTo combine evidence for the efficacy of psychosocial interventions used as adjunctive treatment of bipolar disorder in adults, using network meta-analysis (NMA).MethodSystematic review identified studies and NMA was used to pool data on relapse to mania or depression, medication adherence, and symptom scales for mania, depression and Global Assessment of Functioning (GAF).ResultsCarer-focused interventions significantly reduced the risk of depressive or manic relapse. Psychoeducation alone and in combination with cognitive-behavioural therapy (CBT) significantly reduced medication non-adherence. Psychoeducation plus CBT significantly reduced manic symptoms and increased GAF. No intervention was associated with a significant reduction in depression symptom scale scores.ConclusionsOnly interventions for family members affected relapse rates. Psychoeducation plus CBT reduced medication non-adherence, improved mania symptoms and GAF. Novel methods for addressing depressive symptoms are required.
Language eng
DOI 10.1192/bjp.bp.116.195321
Field of Research 111714 Mental Health
140208 Health Economics
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Royal College of Psychiatrists
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School of Medicine
Population Health
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