Depression in cancer: the many biobehavioral pathways driving tumor progression

Bortolato, Beatrice, Hyphantis, Thomas N., Valpione, Sara, Perini, Giulia, Maes, Michael, Morris, Gerwyn, Kubera, Marta, Köhler, Cristiano A., Fernandes, Brisa S., Stubbs, Brendon, Pavlidis, Nicholas and Carvalho, Andre F. 2017, Depression in cancer: the many biobehavioral pathways driving tumor progression, Cancer treatment reviews, vol. 52, pp. 58-70, doi: 10.1016/j.ctrv.2016.11.004.

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Title Depression in cancer: the many biobehavioral pathways driving tumor progression
Author(s) Bortolato, Beatrice
Hyphantis, Thomas N.
Valpione, Sara
Perini, Giulia
Maes, Michael
Morris, Gerwyn
Kubera, Marta
Köhler, Cristiano A.
Fernandes, Brisa S.ORCID iD for Fernandes, Brisa S.
Stubbs, Brendon
Pavlidis, Nicholas
Carvalho, Andre F.
Journal name Cancer treatment reviews
Volume number 52
Start page 58
End page 70
Total pages 13
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-01
ISSN 0305-7372
Keyword(s) cancer
HPA axis
Major Depressive Disorder
Depressive Disorder, Major
disease progression
Summary Major Depressive Disorder (MDD) is common among cancer patients, with prevalence rates up to four-times higher than the general population. Depression confers worse outcomes, including non-adherence to treatment and increased mortality in the oncology setting. Advances in the understanding of neurobiological underpinnings of depression have revealed shared biobehavioral mechanisms may contribute to cancer progression. Moreover, psychosocial stressors in cancer promote: (1) inflammation and oxidative/nitrosative stress; (2) a decreased immunosurveillance; and (3) a dysfunctional activation of the autonomic nervous system and of the hypothalamic-pituitaryadrenal axis. Consequently, the prompt recognition of depression among patients with cancer who may benefit of treatment strategies targeting depressive symptoms, cognitive dysfunction, fatigue and sleep disturbances, is a public health priority. Moreover, behavioral strategies aiming at reducing psychological distress and depressive symptoms, including addressing unhealthy diet and life-style choices, as well as physical inactivity and sleep dysfunction, may represent important strategies not only to treat depression, but also to improve wider cancer-related outcomes. Herein, we provide a comprehensive review of the intertwined biobehavioral pathways linking depression to cancer progression. In addition, the clinical implications of these findings are critically reviewed.
Language eng
DOI 10.1016/j.ctrv.2016.11.004
Field of Research 111201 Cancer Cell Biology
1112 Oncology And Carcinogenesis
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Elsevier
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Document type: Journal Article
Collection: School of Medicine
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