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Manipulation of dysfunctional spinal joints affects sensorimotor integration in the prefrontal cortex: a brain source localization study

Lelic, Dina, Niazi, Imran Khan, Holt, Kelly, Jochumsen, Mads, Dremstrup, Kim, Yielder, Paul, Murphy, Bernadette, Drewes, Asbjorn Mohr and Haavik, Heidi 2016, Manipulation of dysfunctional spinal joints affects sensorimotor integration in the prefrontal cortex: a brain source localization study, Neural plasticity, vol. 2016, pp. 1-9, doi: 10.1155/2016/3704964.

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Title Manipulation of dysfunctional spinal joints affects sensorimotor integration in the prefrontal cortex: a brain source localization study
Author(s) Lelic, Dina
Niazi, Imran Khan
Holt, Kelly
Jochumsen, Mads
Dremstrup, Kim
Yielder, Paul
Murphy, Bernadette
Drewes, Asbjorn Mohr
Haavik, Heidi
Journal name Neural plasticity
Volume number 2016
Article ID 3704964
Start page 1
End page 9
Total pages 9
Publisher Hindawi
Place of publication New York, N.Y.
Publication date 2016
ISSN 2090-5904
1687-5443
Summary Objectives. Studies have shown decreases in N30 somatosensory evoked potential (SEP) peak amplitudes following spinal manipulation (SM) of dysfunctional segments in subclinical pain (SCP) populations. This study sought to verify these findings and to investigate underlying brain sources that may be responsible for such changes.

Methods.
Nineteen SCP volunteers attended two experimental sessions, SM and control in random order. SEPs from 62-channel EEG cap were recorded following median nerve stimulation (1000 stimuli at 2.3 Hz) before and after either intervention. Peak-to-peak amplitude and latency analysis was completedfor different SEPs peak. Dipolar models of underlying brain sources were built by using the brain electrical source analysis. Twoway repeated measures ANOVA was used to assessed differences in N30 amplitudes, dipole locations, and dipole strengths.

Results.
SM decreased the N30 amplitude by 16.9 ± 31.3% (P = 0.02), while no differences were seen following the control intervention (P = 0.4). Brain source modeling revealed a 4-source model but only the prefrontal source showed reduced activity by 20.2 ± 12.2% (P = 0.03) following SM.

Conclusion.
A single session of spinal manipulation of dysfunctional segments in subclinical pain patients alters somatosensory processing at the cortical level, particularly within the prefrontal cortex.
Language eng
DOI 10.1155/2016/3704964
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091814

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.