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Fattigation-platform theranostic nanoparticles for cancer therapy

Tran, Thao Truong-Dinh, Tran, Phuong Ha-Lien, Yoon, Tae-Jong and Lee, Beom-Jin 2017, Fattigation-platform theranostic nanoparticles for cancer therapy, Materials science and engineering C, vol. 75, pp. 1161-1167, doi: 10.1016/j.msec.2017.03.012.

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Title Fattigation-platform theranostic nanoparticles for cancer therapy
Author(s) Tran, Thao Truong-Dinh
Tran, Phuong Ha-Lien
Yoon, Tae-Jong
Lee, Beom-Jin
Journal name Materials science and engineering C
Volume number 75
Start page 1161
End page 1167
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-06-01
ISSN 0928-4931
Keyword(s) theranostics
magnetic resonance imaging
drug delivery
anticancer drug
treatment-response imaging
Summary A new conceptual nanoparticle consisting of a silica-coated iron oxide magnetic core and a fattigation-based biocompatibleshell with oleic acid and hydrophilic protein (gelatin). The prepared particle can be a usefultheranostics platform material for diagnostic imaging and as a drug delivery system. Oleic acid and gelatinwere conjugated on the silica-coated magnetic nanoparticle surface to provide three primary functionalities:1) enhancing biocompatibility and solubility in aqueous solution and providing the ability to incorporate hydrophobicchemical drugs into the shell for delivery, 2) improving treatment-response magnetic monitoring as a diagnosticagent with lownanotoxicity, and 3) increasing anticancer efficacy owing to the controlled release of theincorporated drug in cells and in an animal model. We prepared magnetic-silica nanoparticles with superparamagneticproperties,which are utilized as a T2-weighted magnetic resonance imaging agent. After formationof an oleic acid-gelatin shell, the prepared materials exhibited high loading capacity for a hydrophobic anticancerdrug (paclitaxel). Our particle platform system exhibited higher therapeutic efficacy and lower toxicological effectsin vitro and in an in vivo cancermodel than a clinically available chemo-drug (Taxol®). Our findings stronglysuggest that this nanoparticle system can serve as a platform for cancer therapy by the incorporation of chemicaldrugs.
Language eng
DOI 10.1016/j.msec.2017.03.012
Field of Research 090399 Biomedical Engineering not elsewhere classified
0903 Biomedical Engineering
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091924

Document type: Journal Article
Collection: School of Medicine
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