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Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells

Ahmed, Nuzhat, Greening, David, Samardzija, Chantel, Escalona, Ruth M., Chen, Maoshan, Findlay, Jock K. and Kannourakis, George 2016, Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells, Scientific reports, vol. 6, pp. 1-13, doi: 10.1038/srep30061.

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Title Unique proteome signature of post-chemotherapy ovarian cancer ascites-derived tumor cells
Author(s) Ahmed, Nuzhat
Greening, David
Samardzija, ChantelORCID iD for Samardzija, Chantel orcid.org/0000-0002-3000-6273
Escalona, Ruth M.
Chen, Maoshan
Findlay, Jock K.
Kannourakis, George
Journal name Scientific reports
Volume number 6
Article ID 30061
Start page 1
End page 13
Total pages 13
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2016-07
ISSN 2045-2322
Summary Eighty % of ovarian cancer patients diagnosed at an advanced-stage have complete remission afterinitial surgery and chemotherapy. However, most patients die within <5 years due to episodesof recurrences resulting from the growth of residual chemoresistant cells. In an effort to identifymechanisms associated with chemoresistance and recurrence, we compared the expression of proteinsin ascites-derived tumor cells isolated from advanced-stage ovarian cancer patients obtained atdiagnosis (chemonaive, CN) and after chemotherapy treatments (chemoresistant/at recurrence, CR)by using in-depth, high-resolution label-free quantitative proteomic profiling. A total of 2,999 proteinswere identified. Using a stringent selection criterion to define only significantly differentially expressedproteins, we report identification of 353 proteins. There were significant differences in proteinsencoding for immune surveillance, DNA repair mechanisms, cytoskeleton rearrangement, cell-celladhesion, cell cycle pathways, cellular transport, and proteins involved with glycine/proline/argininesynthesis in tumor cells isolated from CR relative to CN patients. Pathway analyses revealed enrichmentof metabolic pathways, DNA repair mechanisms and energy metabolism pathways in CR tumor cells.In conclusion, this is the first proteomics study to comprehensively analyze ascites-derived tumor cellsfrom CN and CR ovarian cancer patients.
Language eng
DOI 10.1038/srep30061
Field of Research 111201 Cancer Cell Biology
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30091934

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.