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Muscle microvascular blood flow responses in insulin resistance and ageing

Keske, Michelle A., Premilovac, Dino, Bradley, Eloise A., Dwyer, Renee M., Richards, Stephen M. and Rattigan, Stephen 2016, Muscle microvascular blood flow responses in insulin resistance and ageing, Journal of physiology, vol. 594, no. 8, pp. 2223-2231, doi: 10.1113/jphysiol.2014.283549.

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Title Muscle microvascular blood flow responses in insulin resistance and ageing
Author(s) Keske, Michelle A.
Premilovac, Dino
Bradley, Eloise A.
Dwyer, Renee M.
Richards, Stephen M.
Rattigan, Stephen
Journal name Journal of physiology
Volume number 594
Issue number 8
Start page 2223
End page 2231
Total pages 9
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 2016-04-15
ISSN 1469-7793
Keyword(s) Aging
Animals
Humans
Insulin Resistance
Microcirculation
Microvessels
Muscle, Skeletal
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Physiology
Neurosciences & Neurology
Summary Insulin resistance plays a key role in the development of type 2 diabetes. Skeletal muscle is the major storage site for glucose following a meal and as such has a key role in maintenance of blood glucose concentrations. Insulin resistance is characterised by impaired insulin-mediated glucose disposal in skeletal muscle. Multiple mechanisms can contribute to development of muscle insulin resistance and our research has demonstrated an important role for loss of microvascular function within skeletal muscle. We have shown that insulin can enhance blood flow to the microvasculature in muscle thus improving the access of glucose and insulin to the myocytes to augment glucose disposal. Obesity, insulin resistance and ageing are all associated with impaired microvascular responses to insulin in skeletal muscle. Impairments in insulin-mediated microvascular perfusion in muscle can directly cause insulin resistance, and this event can occur early in the aetiology of this condition. Understanding the mechanisms involved in the loss of microvascular function in muscle has the potential to identify novel treatment strategies to prevent or delay progression of insulin resistance and type 2 diabetes.
Language eng
DOI 10.1113/jphysiol.2014.283549
Field of Research 111603 Systems Physiology
110201 Cardiology (incl Cardiovascular Diseases)
110306 Endocrinology
110602 Exercise Physiology
111103 Nutritional Physiology
06 Biological Sciences
11 Medical And Health Sciences
Socio Economic Objective 920502 Health Related to Ageing
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID NHMRC 1009962
ARC DP0877385
NHMRC 1043474
Copyright notice ©2014, The Authors, Journal of Physiology & The Physiological Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092186

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