Understanding and preventing agglomeration in a filter drying process

Lim, Hong Lee, Hapgood, Karen P. and Haig, Brian 2016, Understanding and preventing agglomeration in a filter drying process, Powder technology, vol. 300, pp. 146-156, doi: 10.1016/j.powtec.2016.03.003.

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Title Understanding and preventing agglomeration in a filter drying process
Author(s) Lim, Hong Lee
Hapgood, Karen P.ORCID iD for Hapgood, Karen P. orcid.org/0000-0002-0402-8954
Haig, Brian
Journal name Powder technology
Volume number 300
Start page 146
End page 156
Total pages 11
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2016-10
ISSN 0032-5910
Keyword(s) filter drying
lump formation
Summary The occurrence of severe agglomeration during a filter drying process is a challenging issue in the pharmaceutical industry and has yet to be fully understood. Product degradation, extended drying times, additional equipment required for the elimination of lumps and downstream processing issues are some of the problems caused by this phenomenon and there is great interest among researchers from various industries to explore how the filtration/drying processing step impacts the agglomeration of powder. This paper investigates the effect of operating condition such as the drying temperature, agitation speed, fill volume and blow-down period on the formation of large agglomerates. In addition, other potential sources of agglomeration such as the dripping of condensates as well as surface tension of wash solvents were also explored. A series of systematic experimental work was carried out using sodium bicarbonate, calcium carbonate and an API intermediate which has high agglomeration tendency to understand behaviour of agglomeration among the different types of powder. It was found that similar trends may be observed in the formation of lumps for different types of powders but the underlying mechanisms of agglomeration were different. The unique behaviour of each powder suggested that a universal solution or mitigation method to eliminate the formation of agglomerate may not be possible. However, by identifying the specific agglomeration mechanisms present in a powder-solvent system, it is possible to carry out the mitigation in a more effective way to minimize the agglomeration.
Language eng
DOI 10.1016/j.powtec.2016.03.003
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2016, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092336

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