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Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders

Qu, Li, Zhou, Qi (Tony), Denman, John A., Stewart, Peter J., Hapgood, Karen P. and Morton, David A.V. 2015, Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders, European journal of pharmaceutical sciences, vol. 78, pp. 264-272, doi: 10.1016/j.ejps.2015.07.016.

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Title Influence of coating material on the flowability and dissolution of dry-coated fine ibuprofen powders
Author(s) Qu, Li
Zhou, Qi (Tony)
Denman, John A.
Stewart, Peter J.
Hapgood, Karen P.
Morton, David A.V.
Journal name European journal of pharmaceutical sciences
Volume number 78
Start page 264
End page 272
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-10-12
ISSN 0928-0987
1879-0720
Keyword(s) Dissolution
Fine cohesive powder
Ibuprofen
Mechanical dry powder coating
Mechanofusion
Powder flow
Fumarates
Leucine
Models, Chemical
Particle Size
Powders
Rheology
Silicon Dioxide
Solubility
Stearic Acids
Surface Properties
Summary This study investigates the effects of a variety of coating materials on the flowability and dissolution of dry-coated cohesive ibuprofen powders, with the ultimate aim to use these in oral dosage forms. A mechanofusion approach was employed to apply a 1% (w/w) dry coating onto ibuprofen powder with coating materials including magnesium stearate (MgSt), L-leucine, sodium stearyl fumarate (SSF) and silica-R972. No significant difference in particle size or shape was measured following mechanofusion with any material. Powder flow behaviours characterised by the Freeman FT4 system indicated coatings of MgSt, L-leucine and silica-R972 produced a notable surface modification and substantially improved flow compared to the unprocessed and SSF-mechanofused powders. ToF-SIMS provided a qualitative measure of coating extent, and indicated a near-complete layer on the drug particle surface after dry coating with MgSt or silica-R972. Of particular note, the dissolution rates of all mechanofused powders were enhanced even with a coating of a highly hydrophobic material such as magnesium stearate. This surprising increase in dissolution rate of the mechanofused powders was attributed to the lower cohesion and the reduced agglomeration after mechanical coating.
Language eng
DOI 10.1016/j.ejps.2015.07.016
Field of Research 1115 Pharmacology And Pharmaceutical Sciences
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2015, Eslevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092351

Document type: Journal Article
Collection: School of Engineering
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