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Lactose microparticle formation from finely atomised droplets

Chew, Sean, Mansouri, Shahnaz, Wardhana, Dimas, Mukhyiddin, Abdurrakhman, Buchmann, Nicolas, Hapgood, Karen, Chen, Xiao Dong and Woo, Meng Wai 2015, Lactose microparticle formation from finely atomised droplets, Chemical engineering science, vol. 122, pp. 395-402, doi: 10.1016/j.ces.2014.10.001.

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Title Lactose microparticle formation from finely atomised droplets
Author(s) Chew, Sean
Mansouri, Shahnaz
Wardhana, Dimas
Mukhyiddin, Abdurrakhman
Buchmann, Nicolas
Hapgood, KarenORCID iD for Hapgood, Karen orcid.org/0000-0002-0402-8954
Chen, Xiao Dong
Woo, Meng Wai
Journal name Chemical engineering science
Volume number 122
Start page 395
End page 402
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-01-27
ISSN 0009-2509
Keyword(s) antisolvent precipitation
microsphere
lactose
antomised droplets
monodisperse
Summary The antisolvent vapour precipitation method has been proven to produce uniformly sized lactose microspheres from a single droplet (~1.2. mm diameter) at atmospheric pressure. These types of particles have potential applications in the pharmaceutical industry, especially due to their high solubility and dissolution rate. This article discusses the possibility of using antisolvent vapour precipitation for finely atomised droplets. Microspheres in the sub-micron scale (~0.4. μm diameter) have been produced, much smaller than those obtained from the single droplet method (~1.0. μm diameter). These particles were not affected by ethanol exposure time (up to 60 s) or drying temperature (up to 190. °C), though the structure was related to the absolute humidity of ethanol. We hypothesise a self-emulsified, two-phase system in the droplet could be the responsible for the formation of the porous and bicontinuous structure as an increase in the absolute humidity resulted in a shrinkage phenomenon which led to the microsphere formation.
Language eng
DOI 10.1016/j.ces.2014.10.001
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092356

Document type: Journal Article
Collection: School of Engineering
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