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Pharmaceutical dry powder blending and scale-up: maintaining equivalent mixing conditions using a coloured tracer powder

Barling, David, Morton, David A.V. and Hapgood, Karen 2015, Pharmaceutical dry powder blending and scale-up: maintaining equivalent mixing conditions using a coloured tracer powder, Powder technology, vol. 270, no. Part B, pp. 461-469, doi: 10.1016/j.powtec.2014.04.069.

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Title Pharmaceutical dry powder blending and scale-up: maintaining equivalent mixing conditions using a coloured tracer powder
Author(s) Barling, David
Morton, David A.V.
Hapgood, KarenORCID iD for Hapgood, Karen orcid.org/0000-0002-0402-8954
Journal name Powder technology
Volume number 270
Issue number Part B
Start page 461
End page 469
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-01
ISSN 0032-5910
1873-328X
Keyword(s) mixing
powder
dispersion
deagglomeration
tracer
pharmaceutical
Summary The identification and optimisation of operating conditions and selection of an appropriate mixer for the manufacturing of pharmaceutical dry powders is extremely challenging, and has relied largely on empirical trial-and-error approaches. A novel extension to a previous method has been proposed, which can be used to quickly and effectively evaluate the progression of a dry powder mixing using a mixing-sensitive coloured tracer powder. A series of lactose powders (white) with 1 wt.% sub-micronised iron oxide tracer (dark red) by weight were blended with three different mixing technologies under a range of processing conditions. Measurement of the hue and hue intensity of the powder blend as a function of time shows two distinct mixing behaviours: dispersion of tracer aggregates through the bulk powder (increase in blend hue intensity) and tracer de-agglomeration into primary particles (hue transition from red to orange). The colourimetric values of samples taken at blending times of up to 1 h were assembled to create a series of formulation-specific colour curves which were able to clearly distinguish and group mixers into low and high intensities given their range of values along the same formulation curves. This iron oxide tracer method provides the basis for a novel quantitative approach for ensuring equivalent blending conditions between mixer types, scales and operating conditions for a given formulation. The approach also shows the potential to identify conditions which may cause unintentional and undesirable particle attrition during powder blending.
Language eng
DOI 10.1016/j.powtec.2014.04.069
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092358

Document type: Journal Article
Collection: School of Engineering
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