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Pharmaceutical particles

Hapgood, Karen, Litster, James D. and Wang, Chi-Hwa 2015, Pharmaceutical particles, Chemical engineering science, vol. 125, pp. 1-3, doi: 10.1016/j.ces.2014.11.021.

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Title Pharmaceutical particles
Author(s) Hapgood, Karen
Litster, James D.
Wang, Chi-Hwa
Journal name Chemical engineering science
Volume number 125
Start page 1
End page 3
Total pages 3
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-03-24
ISSN 0009-2509
Keyword(s) Science & Technology
Technology
Engineering, Chemical
Engineering
Summary Recent developments in the discovery of new medicines haveimproved satisfaction as well as life expectancy of the patientssuffering from diseases. Nevertheless, the physiochemical propertiessuch as bio-availability and water solubility as well as rapid drugmetabolism and clearance from blood systemic circulation haveconfined the optimal prescriptions of drugs at effective pharmacologicaldosage. Although the plasma concentration of drugs may bemaintained at an appropriate level over a short period throughsequential administrations, it may result in higher overall cytotoxicityand severe adverse side effects at healthy organs. Therefore,drug delivery systems (DDS) were proposed as an innovative routefor the sustained and controlled delivery of drugs at pharmacologicalconcentrations to target tissues. The DDS are micro-/nanoparticulatestructures made of biodegradable and biocompatiblematerials, especially biodegradable polymers, which encapsulatepharmaceutical agents and release them through diffusion, degradationand erosion phenomena.
Language eng
DOI 10.1016/j.ces.2014.11.021
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category CN.1 Other journal article
ERA Research output type X Not reportable
Copyright notice ©2014, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092360

Document type: Journal Article
Collection: School of Engineering
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