Unveiling the mechanism of antisolvent vapour precipitation in producing ultrafine spherical particles

Tan, J. Yuan, Tang, V. Menh, Nguyen, J., Chew, S., Mansouri, S., Hapgood, K., Chen, X. Dong and Woo, M. Wai 2015, Unveiling the mechanism of antisolvent vapour precipitation in producing ultrafine spherical particles, Powder technology, vol. 275, pp. 152-160, doi: 10.1016/j.powtec.2015.01.059.

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Title Unveiling the mechanism of antisolvent vapour precipitation in producing ultrafine spherical particles
Author(s) Tan, J. Yuan
Tang, V. Menh
Nguyen, J.
Chew, S.
Mansouri, S.
Hapgood, K.ORCID iD for Hapgood, K. orcid.org/0000-0002-0402-8954
Chen, X. Dong
Woo, M. Wai
Journal name Powder technology
Volume number 275
Start page 152
End page 160
Total pages 9
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2015-05
ISSN 0032-5910
Keyword(s) antisolvent vapor precipitation
polymeric materials
single droplet experiment
liquid phase separation
Science & Technology
Engineering, Chemical
Summary Ultrafine spherical maltodextrin and maltose particles were successfully produced with the antisolvent vapour precipitation (AVP) technique. Comparison between the two materials confirmed that a key requirement for the process is in inhibiting crystallization of the material. The precipitation process consists of: (1) an initial phase separation forming an emulsion formation, (2) phase inversion and (3) finally a water-maltodextrin shrinkage phase which forms the spherical particles driven by interfacial surface tension. Dehydrating the droplet at different stages of the process resulted in various particle morphologies; porous, smooth, microsphere network and microspheres. Higher ethanol relative humidity, higher ethanol absolute humidity and lower initial weight concentration were found to favour the formation of amorphous microspherical particles upon drying.
Language eng
DOI 10.1016/j.powtec.2015.01.059
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Grant ID DP13010483
Copyright notice ©2015, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092367

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