Oxidative and nitrosative stress biomarkers in chronic schizophrenia

Boll, Karine Maria, Noto, Cristiano, Bonifácio, Kamila Landucci, Bortolasci, Chiara Cristina, Gadelha, Ary, Bressan, Rodrigo Affonseca, Barbosa, Decio Sabbatini, Maes, Michael and Moreira, Estefania Gastaldello 2017, Oxidative and nitrosative stress biomarkers in chronic schizophrenia, Psychiatry research, vol. 253, pp. 43-48, doi: 10.1016/j.psychres.2017.03.038.

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Title Oxidative and nitrosative stress biomarkers in chronic schizophrenia
Author(s) Boll, Karine Maria
Noto, Cristiano
Bonifácio, Kamila Landucci
Bortolasci, Chiara CristinaORCID iD for Bortolasci, Chiara Cristina orcid.org/0000-0002-0794-6363
Gadelha, Ary
Bressan, Rodrigo Affonseca
Barbosa, Decio Sabbatini
Maes, Michael
Moreira, Estefania Gastaldello
Journal name Psychiatry research
Volume number 253
Start page 43
End page 48
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-07
ISSN 0165-1781
Summary There is evidence that the acute phase of schizophrenia (SCZ) is accompanied by specific changes in oxidative and nitrosative stress (O&NS) biomarkers. There are, however, no firm data regarding these biomarkers in chronic SCZ. Therefore, this study aimed to delineate O&NS biomarkers in patients with chronic SCZ. 125 outpatients with SCZ and 118 controls were enrolled. The markers included lipid hydroperoxides (LOOH), advanced oxidation protein products (AOPP), nitric oxide metabolites (NOx), total radical-trapping antioxidant parameter (TRAP) and paraoxonase 1 (PON-1) activity. Immune-inflammatory markers known to be altered in SCZ were also measured: leptin, IL-6, soluble TNF receptors (sTNF-Rs) and the chemokines CCL-11 and CCL-3. There were no significant associations between chronic SCZ and the O&NS markers (AOPP, NOx, LOOH) and the anti-oxidants PON-1 and TRAP. Leptin, sTNF-R, CCL-3 and CCL-11 were significantly higher in SCZ. There were significant associations between pro-inflammatory and O&NS biomarkers (leptin/CCL-8 and AOPP; IL-6 and NOx; CCL-3 and LOOH; CCL-3/IL-6/NOx and TRAP). In conclusion, there were significant intercorrelations between inflammatory and O&NS pathways, which play a role in the pathophysiology of chronic SCZ. O&NS markers and the enzyme PON-1 are not useful as biomarkers in chronic stable polymedicated SCZ patients.
Language eng
DOI 10.1016/j.psychres.2017.03.038
Field of Research 170199 Psychology not elsewhere classified
11 Medical And Health Sciences
17 Psychology And Cognitive Sciences
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092824

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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