Foam granulation: effects of formulation and process conditions on granule size distributions

Tan, Melvin X.L. and Hapgood, Karen P. 2012, Foam granulation: effects of formulation and process conditions on granule size distributions, Powder technology, vol. 218, pp. 149-156, doi: 10.1016/j.powtec.2011.12.006.

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Title Foam granulation: effects of formulation and process conditions on granule size distributions
Author(s) Tan, Melvin X.L.
Hapgood, Karen P.ORCID iD for Hapgood, Karen P.
Journal name Powder technology
Volume number 218
Start page 149
End page 156
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2012-03
ISSN 0032-5910
Keyword(s) agglomeration
high shear mixer
Science & Technology
Engineering, Chemical
Summary The use of foam to achieve granulation is a new development in wet granulation processes. This paper studies foam granulation by investigating the impact of formulation and granulation process conditions on the granule size distribution in a high shear mixer-granulator. Experimental studies were performed in a high shear mixer-granulator on a lactose and microcrystalline cellulose (PH-101) formulation. The granule size distributions were determined as a function of foam quality (83% or 91%), primary powder particle size (75 μm or 150 μm), HPMC binder concentration (4% or 8%), liquid to solid ratio (20-60%), and impeller rotational speed (295. rpm or 515. rpm).The results showed that decreasing foam quality, or increasing the lactose particle size, liquid binder concentration or liquid to solid ratio increase the average granule size, but the effect is interconnected with impeller speed. Transformation maps were proposed to explain the changes in granule size distribution in response to changes of the studied parameters on the basis of wetting and nucleation mechanisms for foam granulation process.
Language eng
DOI 10.1016/j.powtec.2011.12.006
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, Elsevier
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