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Vitamin D, bones and muscle: myth versus reality

Duque, Gustavo, Daly, Robin M., Sanders, Kerrie and Kiel, Douglas P. 2017, Vitamin D, bones and muscle: myth versus reality, Australasian journal on ageing, vol. 36, no. Suppl 1, pp. 8-13, doi: 10.1111/ajag.12408.

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Title Vitamin D, bones and muscle: myth versus reality
Author(s) Duque, Gustavo
Daly, Robin M.ORCID iD for Daly, Robin M. orcid.org/0000-0002-9897-1598
Sanders, Kerrie
Kiel, Douglas P.
Journal name Australasian journal on ageing
Volume number 36
Issue number Suppl 1
Start page 8
End page 13
Total pages 6
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 2017-03
ISSN 1741-6612
Keyword(s) falls
fractures
osteoporosis
sarcopenia
vitamin D
Accidental Falls
Age Factors
Aged
Aged, 80 and over
Aging
Animals
Biomarkers
Bone Remodeling
Dietary Supplements
Evidence-Based Medicine
Frail Elderly
Humans
Muscle Strength
Osteoporotic Fractures
Risk Factors
Vitamin D Deficiency
Summary OBJECTIVES: Evidence regarding the efficacy and dosing of vitamin D on fall and fracture prevention, with or without calcium, is characterised by uncertainty. METHODS: A panel of experts was organised at the First Australasian Conference on Sarcopenia and Frailty in Melbourne, Australia, in November 2016 to provide an interpretation of the current evidence and to give their opinions regarding the supplementation of vitamin D in three hypothetical cases. RESULTS AND CONCLUSION: The authors conclude that (i) target serum 25(OH)D concentration should be 50 to 60 nmol/L year round, with a conservative upper limit <100 nmol/L; (ii) change in serum concentrations at any given dose is highly variable among individuals; (iii) dosing interval may need to be <2 months to have a continuous benefit; (iv) a loading dose can raise levels to target quickly, but there is no evidence yet that this has any positive effect on falls or fracture outcomes; and (v) a maintenance dose of 1000 IU/day, or given as an equivalent dose weekly or monthly, is sufficient for most individuals.
Notes Special Issue: First Australia and New Zealand Conference on Sarcopenia and Frailty Research, 11–12 November 2016, Pullman Melbourne AlbertPark, Victoria
Language eng
DOI 10.1111/ajag.12408
Field of Research 111699 Medical Physiology not elsewhere classified
110306 Endocrinology
111199 Nutrition and Dietetics not elsewhere classified
110308 Geriatrics and Gerontology
11 Medical And Health Sciences
16 Studies In Human Society
17 Psychology And Cognitive Sciences
Socio Economic Objective 920116 Skeletal System and Disorders (incl. Arthritis)
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, AJA
Persistent URL http://hdl.handle.net/10536/DRO/DU:30092948

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