Wet granulation and mixing

Hapgood, Karen and Smith, Rachel M. 2015, Wet granulation and mixing. In Cullen, P.J., Romañach, Rodolfo J., Abatzoglou, Nicolas and Rielly, Chris D. (ed), Pharmaceutical blending and mixing, John Wiley & Sons, Chichester, Eng., pp.153-182, doi: 10.1002/9781118682692.ch8.

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Title Wet granulation and mixing
Author(s) Hapgood, KarenORCID iD for Hapgood, Karen orcid.org/0000-0002-0402-8954
Smith, Rachel M.
Title of book Pharmaceutical blending and mixing
Editor(s) Cullen, P.J.
Romañach, Rodolfo J.
Abatzoglou, Nicolas
Rielly, Chris D.
Publication date 2015
Chapter number 8
Total chapters 17
Start page 153
End page 182
Total pages 30
Publisher John Wiley & Sons
Place of Publication Chichester, Eng.
Keyword(s) agitated powder bed
binder material
fluid bed granulators
mixer granulators
sieve fraction assay
size fractions
wet granulation
Summary Granulation is a size enlargement process in which mixtures of fine powders are combined into larger agglomerates or granules. In wet granulation, a liquid and a binder material are added to an agitated powder bed to form granules. Common types of wet granulation equipment used in the pharmaceutical industry include mixer granulators where the powder is agitated by a large impeller at the base of mixer bowl, or fluid bed granulators where air is blown upwards through the powder to agitate and fluidize the particles. Drying of the granules drives off the liquid but a network of solid bridges and polymeric chains give strength and cohesion to the new granules. A simple method to analyse the extent of blending and mixing of drug after wet granulation is to conduct a 'sieve fraction assay', where the granules are sieved into size fractions and each size fraction is assayed for drug content.
ISBN 9780470710555
Language eng
DOI 10.1002/9781118682692.ch8
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
Socio Economic Objective 0 Not Applicable
HERDC Research category B1.1 Book chapter
ERA Research output type B Book chapter
Copyright notice ©2015, John Wiley & Sons
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093114

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