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Foam granulation: liquid penetration or mechanical dispersion?

Tan, Melvin X.L. and Hapgood, Karen P. 2011, Foam granulation: liquid penetration or mechanical dispersion?, Chemical engineering science, vol. 66, no. 21, pp. 5204-5211, doi: 10.1016/j.ces.2011.07.012.

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Title Foam granulation: liquid penetration or mechanical dispersion?
Author(s) Tan, Melvin X.L.
Hapgood, Karen P.
Journal name Chemical engineering science
Volume number 66
Issue number 21
Start page 5204
End page 5211
Total pages 8
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2011-11-01
ISSN 0009-2509
Keyword(s) agglomeration
foam
granulation
granule size distribution
high shear mixer nucleation
Summary There have been significant advances in the understanding of wet granulation processes. Foam granulation is the latest development and an emerging area of interest for pharmaceutical manufacturing.Single foam penetration experiments were carried out on static powder beds, followed by short-nucleation experiments (where nuclei are formed by a nucleation-only mechanism) and full foam granulation experiments (where nucleation, growth and breakage are occurring simultaneously). All experiments were performed with lactose monohydrate powder using a 5. L high shear mixer-granulator. The foam penetration/dispersion behaviour was examined and the granule size distributions were investigated as a function of foam quality (83-97% FQ), impeller speed (105-515. rpm) and wet massing period (0-4. min).Nucleation in foam granulation is postulated to undergo either "foam drainage" or "mechanical dispersion" controlled mechanisms. For "foam drainage" mechanism, the foam penetrates the powder bed to form coarse and broad granule size distributions. For "mechanical dispersion" mechanism, the wetting and nucleation conditions are governed by the powder mixing conditions and similar granule size distributions are produced. Regardless of the mechanism, the initial wetting and nucleation behaviour controls the initial nuclei size distribution, and this initial distribution is retained in the final granule size distribution. This work demonstrated the critical importance of the nucleation and binder distribution in determining the granule size distributions for foam granulation process.
Language eng
DOI 10.1016/j.ces.2011.07.012
Field of Research 0904 Chemical Engineering
0913 Mechanical Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2011, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093121

Document type: Journal Article
Collection: School of Engineering
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