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Nutritional psychiatry: where to next?

Jacka, Felice N. 2017, Nutritional psychiatry: where to next?, EBioMedicine, vol. 17, pp. 24-29, doi: 10.1016/j.ebiom.2017.02.020.

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Title Nutritional psychiatry: where to next?
Author(s) Jacka, Felice N.ORCID iD for Jacka, Felice N.
Journal name EBioMedicine
Volume number 17
Start page 24
End page 29
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-03
ISSN 2352-3964
Keyword(s) Depression
Mental disorder
Attention Deficit Disorder with Hyperactivity
Diet Therapy
Dietary Supplements
Summary The nascent field of ‘Nutritional Psychiatry’ offers much promise for addressing the large disease burden associated with mental disorders. A consistent evidence base from the observational literature confirms that the quality of individuals' diets is related to their risk for common mental disorders, such as depression. This is the case across countries and age groups. Moreover, new intervention studies implementing dietary changes suggest promise for the prevention and treatment of depression. Concurrently, data point to the utility of selected nutraceuticals as adjunctive treatments for mental disorders and as monotherapies for conditions such as ADHD. Finally, new studies focused on understanding the biological pathways that mediate the observed relationships between diet, nutrition and mental health are pointing to the immune system, oxidative biology, brain plasticity and the microbiome-gut-brain axis as key targets for nutritional interventions. On the other hand, the field is currently limited by a lack of data and methodological issues such as heterogeneity, residual confounding, measurement error, and challenges in measuring and ensuring dietary adherence in intervention studies. Key challenges for the field are to now: replicate, refine and scale up promising clinical and population level dietary strategies; identify a clear set of biological pathways and targets that mediate the identified associations; conduct scientifically rigorous nutraceutical and ‘psychobiotic’ interventions that also examine predictors of treatment response; conduct observational and experimental studies in psychosis focused on dietary and related risk factors and treatments; and continue to advocate for policy change to improve the food environment at the population level.
Language eng
DOI 10.1016/j.ebiom.2017.02.020
Socio Economic Objective 0 Not Applicable
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
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