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Plasmodium falciparum Rab1A localizes to rhoptries in schizonts

Morse, David, Webster, Wesley, Kalanon, Ming, Langsley, Gordon and McFadden, Geoffrey I. 2016, Plasmodium falciparum Rab1A localizes to rhoptries in schizonts, PLoS one, vol. 11, no. 6, pp. 1-13, doi: 10.1371/journal.pone.0158174.

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Title Plasmodium falciparum Rab1A localizes to rhoptries in schizonts
Formatted title Plasmodium falciparum Rab1A localizes to rhoptries in schizonts
Author(s) Morse, David
Webster, Wesley
Kalanon, Ming
Langsley, Gordon
McFadden, Geoffrey I.
Journal name PLoS one
Volume number 11
Issue number 6
Article ID e0158174
Start page 1
End page 13
Total pages 13
Publisher Public Library of Science
Place of publication San Francisco, Calif.
Publication date 2016-06-27
ISSN 1932-6203
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
EARLY ENDOCYTIC PATHWAY
TOXOPLASMA-GONDII
ENDOPLASMIC-RETICULUM
SECRETORY ORGANELLE
PROTEIN
TRANSPORT
BIOGENESIS
GTPASE
FUSION
FAMILY
Summary Over-expression of a GFP-PfRab1A fusion protein in Plasmodium falciparum schizonts produces a punctate pattern of fluorescence typical of rhoptries, secretory organelles involved in host cell invasion. The GFP-positive bodies were purified by a combination of differential and density gradient centrifugation and their protein content determined by MS/MS sequencing. Consistent with the GFP rhoptry-like pattern of transgenic parasites, four of the 19 proteins identified have been previously described to be rhoptry-associated and another four are ER or ER-associated proteins. Confirmation that GFP-PfRab1A decorates rhoptries was obtained by its co-localization with Rap1 and Ron4 in late phase schizonts. We conclude that PfRab1A potentially regulates vesicular traffic from the endoplasmic reticulum to the rhoptries in Apicomplexa parasites.
Language eng
DOI 10.1371/journal.pone.0158174
Field of Research 110799 Immunology not elsewhere classified
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093175

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.