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Mushroom lectins as promising anticancer substances

Singh, Ram Sarup, Kaur, Hemant Preet and Kanwar, Jagat Rakesh 2016, Mushroom lectins as promising anticancer substances, Current protein & peptide science, vol. 17, no. 8, pp. 797-807, doi: 10.2174/1389203717666160226144741.


Title Mushroom lectins as promising anticancer substances
Author(s) Singh, Ram Sarup
Kaur, Hemant Preet
Kanwar, Jagat Rakesh
Journal name Current protein & peptide science
Volume number 17
Issue number 8
Start page 797
End page 807
Total pages 11
Publisher Bentham Science
Place of publication Beijing, China
Publication date 2016
ISSN 1389-2037
1875-5550
Keyword(s) anticancer agents
antiproliferative activity
apoptosis
cancer
lectins
mushrooms
Agaricales
Antineoplastic Agents
Cell Line, Tumor
Cell Membrane
Cell Proliferation
Cell Wall
Fungal Proteins
Humans
Neoplasms
Science & Technology
Life Sciences & Biomedicine
Biochemistry & Molecular Biology
AGARICUS-BISPORUS LECTIN
BOLETUS-SATANAS LENZ
TRANSCRIPTASE INHIBITORY-ACTIVITIES
EPITHELIAL-CELL BEHAVIOR
NUCLEAR-PROTEIN IMPORT
EDIBLE MUSHROOM
AGROCYBE-AEGERITA
TOXIC PROTEIN
XEROCOMUS-CHRYSENTERON
Summary Lectins are proteins/glycoproteins of non-immune origin, which are widely distributed in nature. They have at least one non-catalytic domain, which binds reversibly to specific monosaccharides or oligosaccharides. Lectins recognizing sugar moieties in cell walls or cell membranes alter the membrane physiology and trigger biochemical changes in the cell. Thus, various applications of lectins have been described, for example as tools to identify aberrant glycans expressed by neoplastic cells and as antitumor agents by inducing apoptosis by various mechanisms. In order to widen applications of anti-tumor lectins, a detailed investigation of their action mechanism is required. Mushrooms are a valuable source of novel lectins with unique specificities and potentials for biotechnological and biomedical applications. This article reviews information on anti-proliferative activity of mushroom lectins obtained in-vitro and in-vivo. The possible role of lectins as cancer therapeutics is discussed together with the mechanisms underlying the anti-proliferative activity, which may help to exploit these biomolecules as potential novel antitumor drugs in near future.
Language eng
DOI 10.2174/1389203717666160226144741
Field of Research 030499 Medicinal and Biomolecular Chemistry not elsewhere classified
0304 Medicinal And Biomolecular Chemistry
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Bentham Science
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093176

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
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