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Clinical trials of medicinal cannabis for appetite-related symptoms from advanced cancer: a survey of preferences, attitudes and beliefs among patients willing to consider participation

Luckett, T., Phillips, J., Lintzeris, N., Allsop, D., Lee, J., Solowij, N., Martin, J., Lam, L., Aggarwal, R., McCaffrey, Nikki, Currow, D., Chye, R., Lovell, M., McGregor, I. and Agar, M. 2016, Clinical trials of medicinal cannabis for appetite-related symptoms from advanced cancer: a survey of preferences, attitudes and beliefs among patients willing to consider participation, Internal medicine journal, vol. 46, no. 11, pp. 1269-1275, doi: 10.1111/imj.13224.

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Title Clinical trials of medicinal cannabis for appetite-related symptoms from advanced cancer: a survey of preferences, attitudes and beliefs among patients willing to consider participation
Author(s) Luckett, T.
Phillips, J.
Lintzeris, N.
Allsop, D.
Lee, J.
Solowij, N.
Martin, J.
Lam, L.
Aggarwal, R.
McCaffrey, NikkiORCID iD for McCaffrey, Nikki orcid.org/0000-0003-3684-3723
Currow, D.
Chye, R.
Lovell, M.
McGregor, I.
Agar, M.
Journal name Internal medicine journal
Volume number 46
Issue number 11
Start page 1269
End page 1275
Total pages 7
Publisher Wiley
Place of publication Milton, Qld.
Publication date 2016-11-03
ISSN 1444-0903
1445-5994
Keyword(s) cannabis
cancer
clinical trial
attitude
anorexia
Summary Background: Australian clinical trials are planned to evaluate medicinal cannabis in a range of clinical contexts.

Aims: To explore the preferences, attitudes and beliefs of patients eligible and willing to consider participation in a clinical trial of medicinal cannabis for poor appetite and appetite-related symptoms from advanced cancer.

Methods: A cross-sectional anonymous survey was administered from July to December 2015 online and in eight adult outpatient palliative care and/or cancer services. Respondents were eligible if they were ≥18 years, had advanced cancer and poor appetite/taste problems/weight loss and might consider participating in a medicinal cannabis trial. Survey items focused on medicinal rather than recreational cannabis use and did not specify botanical or pharmaceutical products. Items asked about previous medicinal cannabis use and preferences for delivery route and invited comments and concerns.

Results: There were 204 survey respondents, of whom 26 (13%) reported prior medicinal cannabis use. Tablets/capsules were the preferred delivery mode (n = 144, 71%), followed by mouth spray (n = 84, 42%) and vaporiser (n = 83, 41%). Explanations for preferences (n = 134) most commonly cited convenience (n = 66; 49%). A total of 82% (n = 168) of respondents indicated that they had no trial-related concerns, but a small number volunteered concerns about adverse effects (n = 14) or wanted more information/advice (n = 8). Six respondents volunteered a belief that cannabis might cure cancer, while two wanted assurance of efficacy before participating in a trial.

Conclusion: Justification of modes other than tablets/capsules and variable understanding about cannabis and trials will need addressing in trial-related information to optimise recruitment and ensure that consent is properly informed.
Language eng
DOI 10.1111/imj.13224
Field of Research 110399 Clinical Sciences not elsewhere classified
1103 Clinical Sciences
1117 Public Health And Health Services
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Royal Australasian College of Physicians
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093381

Document type: Journal Article
Collection: School of Health and Social Development
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