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The role of the gut microbiota in NAFLD

Leung, Christopher, Rivera, Leni, Furness, John B. and Angus, Peter W. 2016, The role of the gut microbiota in NAFLD, Nature reviews gastroenterology and hepatology, vol. 13, no. 7, pp. 412-425, doi: 10.1038/nrgastro.2016.85.

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Title The role of the gut microbiota in NAFLD
Author(s) Leung, Christopher
Rivera, Leni
Furness, John B.
Angus, Peter W.
Journal name Nature reviews gastroenterology and hepatology
Volume number 13
Issue number 7
Start page 412
End page 425
Total pages 14
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2016-07
ISSN 1759-5045
1759-5053
Keyword(s) dysbiosis
microbiota
non-alcoholic fatty liver disease
pathogenesis
Summary NAFLD is now the most common cause of liver disease in Western countries. This Review explores the links between NAFLD, the metabolic syndrome, dysbiosis, poor diet and gut health. Animal studies in which the gut microbiota are manipulated, and observational studies in patients with NAFLD, have provided considerable evidence that dysbiosis contributes to the pathogenesis of NAFLD. Dysbiosis increases gut permeability to bacterial products and increases hepatic exposure to injurious substances that increase hepatic inflammation and fibrosis. Dysbiosis, combined with poor diet, also changes luminal metabolism of food substrates, such as increased production of certain short-chain fatty acids and alcohol, and depletion of choline. Changes to the microbiome can also cause dysmotility, gut inflammation and other immunological changes in the gut that might contribute to liver injury. Evidence also suggests that certain food components and lifestyle factors, which are known to influence the severity of NAFLD, do so at least in part by changing the gut microbiota. Improved methods of analysis of the gut microbiome, and greater understanding of interactions between dysbiosis, diet, environmental factors and their effects on the gut-liver axis should improve the treatment of this common liver disease and its associated disorders.
Language eng
DOI 10.1038/nrgastro.2016.85
Field of Research 110399 Clinical Sciences not elsewhere classified
Socio Economic Objective 920105 Digestive System Disorders
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, Macmillan Publishers
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093622

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
School of Medicine
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