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Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary

Samardzija, Chantel, Quinn, Michael, Findlay, Jock K. and Ahmed, Nuzhat 2012, Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary, Journal of ovarian research, vol. 5, pp. 1-12, doi: 10.1186/1757-2215-5-37.

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Title Attributes of Oct4 in stem cell biology: perspectives on cancer stem cells of the ovary
Author(s) Samardzija, ChantelORCID iD for Samardzija, Chantel orcid.org/0000-0002-3000-6273
Quinn, Michael
Findlay, Jock K.
Ahmed, Nuzhat
Journal name Journal of ovarian research
Volume number 5
Article ID 37
Start page 1
End page 12
Total pages 12
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2012-11
ISSN 1757-2215
Keyword(s) Ovarian carcinoma
Cancer stem cell
Metastasis
Chemorisistance
Recurrence
Embryonic stem cells
Induced pluripotent stem cells
Summary Epithelial ovarian cancer (EOC) remains the most lethal of all the gynaecological malignancies with drug resistance and recurrence remaining the major therapeutic barrier in the management of the disease. Although several studies have been undertaken to understand the mechanisms responsible for chemoresistance and subsequent recurrence in EOC, the exact mechanisms associated with chemoresistance/recurrence continue to remain elusive. Recent studies have shown that the parallel characteristics commonly seen between embryonic stem cells (ESCs) and induced pluripotent stem cells (iPSC) are also shared by a relatively rare population of cells within tumors that display stem cell-like features. These cells, termed ‘cancer initiating cells’ or ‘cancer stem cells (CSCs)’ have been shown not only to display increased self renewal and pluripotent abilities as seen in ESCs and iPSCs, but are also highly tumorigenic in in vivo mouse models. Additionally, these CSCs have been implicated in tumor recurrence and chemoresistance, and when isolated have consistently shown to express the master pluripotency and embryonic stem cell regulating gene Oct4. This article reviews the involvement of Oct4 in cancer progression and chemoresistance, with emphasis on ovarian cancer. Overall, we highlight why ovarian cancer patients, who initially respond to conventional chemotherapy subsequently relapse with recurrent chemoresistant disease that is essentially incurable.
Language eng
DOI 10.1186/1757-2215-5-37
Field of Research 111299 Oncology and Carcinogenesis not elsewhere classified
Socio Economic Objective 920102 Cancer and Related Disorders
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2012, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093728

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.