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Oxidative stress and frailty: a systematic review and synthesis of the best evidence

Soysal, Pinar, Isik, Ahmet Turan, Carvalho, Andre F., Fernandes, Brisa S., Solmi, Marco, Schofield, Patricia, Veronese, Nicola and Stubbs, Brendon 2017, Oxidative stress and frailty: a systematic review and synthesis of the best evidence, Maturitas, vol. 99, pp. 66-72, doi: 10.1016/j.maturitas.2017.01.006.

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Title Oxidative stress and frailty: a systematic review and synthesis of the best evidence
Author(s) Soysal, Pinar
Isik, Ahmet Turan
Carvalho, Andre F.
Fernandes, Brisa S.ORCID iD for Fernandes, Brisa S. orcid.org/0000-0002-3797-7582
Solmi, Marco
Schofield, Patricia
Veronese, Nicola
Stubbs, Brendon
Journal name Maturitas
Volume number 99
Start page 66
End page 72
Total pages 7
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-05
ISSN 0378-5122
1873-4111
Keyword(s) Anti-oxidant
Frail
Frailty
Oxidative stress
1-Alkyl-2-acetylglycerophosphocholine Esterase
Aged
Aged, 80 and over
Aging
Aldehydes
Biomarkers
Cross-Sectional Studies
Deoxyguanosine
Frail Elderly
Glutathione
Glutathione Disulfide
Humans
Isoprostanes
Longitudinal Studies
Reactive Oxygen Species
Sulfhydryl Compounds
alpha-Tocopherol
Summary OBJECTIVE: Oxidative stress (OS) is associated with accelerated aging. Previous studies have suggested a possible relationship between OS and frailty but this association remains unclear. We conducted a systematic review to investigate potential interactions between OS and frailty. METHODS: A systematic literature search of original reports providing data on 'OS and antioxidant' parameters and frailty was carried out across major electronic databases from inception until May 2016. Cross-sectional/case control and longitudinal studies reporting data on the association between frailty and anti-oxidants-OS biomarkers were considered for inclusion. Results were summarized with a synthesis based on the best evidence. RESULTS: From 1856 hits, 8 studies (cross-sectional/case control) were included (N=6349; mean age of 75±12years; 56.4% females). Overall, there were 588 (=9.3%) frail, 3036 pre-frail (=47.8%), 40 (=0.6%) pre-frail/robust, and 2685 (=42.3%) robust subjects. Six cross-sectional/case control studies demonstrated that frailty was associated with an increase in peripheral OS biomarkers, including lipoprotein phospholipase A2 (1 study), isoprostanes (2 studies), malonaldehyde (2 studies), 8-hydroxy-20-deoxyguanosine (2 studies), derivate of reactive oxygen metabolites (2 studies), oxidized glutathione/glutathione (1 study), 4-hydroxy-2,3-nonenal (1 study), and protein carbonylation levels (1 study). In addition, preliminary evidence points to lower anti-oxidant parameters (vitamin C, E, α-tocopherol, biological anti-oxidant potential, total thiol levels) in frailty. CONCLUSION: Frailty and pre-frailty appear to be associated with higher OS and possibly lower anti-oxidant parameters. However, due to the cross-sectional design, it is not possible to disentangle the directionality of the relationships observed. Thus, future high-quality and in particular longitudinal research is required to confirm or refute these relationships and to further elucidate pathophysiological mechanisms.
Language eng
DOI 10.1016/j.maturitas.2017.01.006
Field of Research 110399 Clinical Sciences not elsewhere classified
1103 Clinical Sciences
1114 Paediatrics And Reproductive Medicine
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Elsevier
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093767

Document type: Journal Article
Collection: School of Medicine
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