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Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?

Smith, Craig M., Walker, Andrew W., Hosken, Ihaia T., Chua, Berenice E., Zhang, Cary, Haidar, Mouna and Gundlach, Andrew L. 2014, Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?, Frontiers in pharmacology, vol. 5, pp. 1-17, doi: 10.3389/fphar.2014.00046.

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Title Relaxin-3/RXFP3 networks: an emerging target for the treatment of depression and other neuropsychiatric diseases?
Author(s) Smith, Craig M.ORCID iD for Smith, Craig M. orcid.org/0000-0002-2894-2433
Walker, Andrew W.
Hosken, Ihaia T.
Chua, Berenice E.
Zhang, Cary
Haidar, Mouna
Gundlach, Andrew L.
Journal name Frontiers in pharmacology
Volume number 5
Article ID 46
Start page 1
End page 17
Total pages 17
Publisher Frontiers Research Foundation
Place of publication Lausanne, Switzerland
Publication date 2014-03
ISSN 1663-9812
Keyword(s) relaxin-3
RXFP3
neuropeptide
arousal
stress
mood and depression
autism spectrum disorders
eating disorders
Science & Technology
Life Sciences & Biomedicine
Pharmacology & Pharmacy
CORTICOTROPIN-RELEASING-FACTOR
HIPPOCAMPAL-THETA-RHYTHM
CENTRAL-NERVOUS-SYSTEM
INTERGENICULATE LEAFLET NEURONS
RELAXIN FAMILY PEPTIDES
RECEPTOR MESSENGER-RNA
DORSAL RAPHE NUCLEUS
MALE WISTAR RATS
NEUROPEPTIDE-Y
STRIA TERMINALIS
Summary Animal and clinical studies of gene-environment interactions have helped elucidate the mechanisms involved in the pathophysiology of several mental illnesses including anxiety, depression, and schizophrenia; and have led to the discovery of improved treatments. The study of neuropeptides and their receptors is a parallel frontier of neuropsychopharmacology research and has revealed the involvement of several peptide systems in mental illnesses and identified novel targets for their treatment. Relaxin-3 is a newly discovered neuropeptide that binds, and activates the G-protein coupled receptor, RXFP3. Existing anatomical and functional evidence suggests relaxin-3 is an arousal transmitter which is highly responsive to environmental stimuli, particularly neurogenic stressors, and in turn modulates behavioral responses to these stressors and alters key neural processes, including hippocampal theta rhythm and associated learning and memory. Here, we review published experimental data on relaxin-3/RXFP3 systems in rodents, and attempt to highlight aspects that are relevant and/or potentially translatable to the etiology and treatment of major depression and anxiety. Evidence pertinent to autism spectrum and metabolism/eating disorders, or related psychiatric conditions, is also discussed. We also nominate some key experimental studies required to better establish the therapeutic potential of this intriguing neuromodulatory signaling system, including an examination of the impact of RXFP3 agonists and antagonists on the overall activity of distinct or common neural substrates and circuitry that are identified as dysfunctional in these debilitating brain diseases.
Language eng
DOI 10.3389/fphar.2014.00046
Field of Research 111599 Pharmacology and Pharmaceutical Sciences not elsewhere classified
1115 Pharmacology And Pharmaceutical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2014, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093783

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.