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A genetic epidemiological mega analysis of smoking initiation in adolescents

Maes, Hermine H., Prom-Wormley, Elizabeth, Eaves, Lindon J., Rhee, Soo Hyun, Hewitt, John K., Young, Susan, Corley, Robin, McGue, Matt, Iacono, William G., Legrand, Lisa, Samek, Diana R., Murrelle, E. Lenn, Silberg, Judy L., Miles, Donna R., Schieken, Richard M., Beunen, Gaston P., Thomis, Martine, Rose, Richard J., Dick, Danielle M., Boomsma, Dorret I., Bartels, Meike, Vink, Jacqueline M., Lichtenstein, Paul, White, Victoria, Kaprio, Jaakko and Neale, Michael C. 2017, A genetic epidemiological mega analysis of smoking initiation in adolescents, Nicotine & tobacco research, vol. 19, no. 4, pp. 401-409, doi: 10.1093/ntr/ntw294.

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Title A genetic epidemiological mega analysis of smoking initiation in adolescents
Author(s) Maes, Hermine H.
Prom-Wormley, Elizabeth
Eaves, Lindon J.
Rhee, Soo Hyun
Hewitt, John K.
Young, Susan
Corley, Robin
McGue, Matt
Iacono, William G.
Legrand, Lisa
Samek, Diana R.
Murrelle, E. Lenn
Silberg, Judy L.
Miles, Donna R.
Schieken, Richard M.
Beunen, Gaston P.
Thomis, Martine
Rose, Richard J.
Dick, Danielle M.
Boomsma, Dorret I.
Bartels, Meike
Vink, Jacqueline M.
Lichtenstein, Paul
White, VictoriaORCID iD for White, Victoria orcid.org/0000-0001-6619-8484
Kaprio, Jaakko
Neale, Michael C.
Journal name Nicotine & tobacco research
Volume number 19
Issue number 4
Start page 401
End page 409
Total pages 9
Publisher Oxford University Press
Place of publication Oxford, Eng.
Publication date 2017-04-01
ISSN 1462-2203
1469-994X
Keyword(s) smoking
adolescent
environmental factors
adult
Australia
relationship - sibling
smoke
twins
genetics
genetic aspects
causality
Summary Introduction: Previous studies in adolescents were not adequately powered to accurately disentangle genetic and environmental influences on smoking initiation (SI) across adolescence.

Methods: Mega-analysis of pooled genetically informative data on SI was performed, with structural equation modeling, to test equality of prevalence and correlations across cultural backgrounds, and to estimate the significance and effect size of genetic and environmental effects according to the classical twin study, in adolescent male and female twins from same-sex and opposite-sex twin pairs (N = 19 313 pairs) between ages 10 and 19, with 76 358 longitudinal assessments between 1983 and 2007, from 11 population-based twin samples from the United States, Europe, and Australia.

Results: Although prevalences differed between samples, twin correlations did not, suggesting similar etiology of SI across developed countries. The estimate of additive genetic contributions to liability of SI increased from approximately 15% to 45% from ages 13 to 19. Correspondingly, shared environmental factors accounted for a substantial proportion of variance in liability to SI at age 13 (70%) and gradually less by age 19 (40%).

Conclusions: Both additive genetic and shared environmental factors significantly contribute to variance in SI throughout adolescence. The present study, the largest genetic epidemiological study on SI to date, found consistent results across 11 studies for the etiology of SI. Environmental factors, especially those shared by siblings in a family, primarily influence SI variance in early adolescence, while an increasing role of genetic factors is seen at later ages, which has important implications for prevention strategies.

Implications: This is the first study to find evidence of genetic factors in liability to SI at ages as young as 12. It also shows the strongest evidence to date for decay of effects of the shared environment from early adolescence to young adulthood. We found remarkable consistency of twin correlations across studies reflecting similar etiology of liability to initiate smoking across different cultures and time periods. Thus familial factors strongly contribute to individual differences in who starts to smoke with a gradual increase in the impact of genetic factors and a corresponding decrease in that of the shared environment.
Language eng
DOI 10.1093/ntr/ntw294
Field of Research 111799 Public Health and Health Services not elsewhere classified
1117 Public Health And Health Services
1103 Clinical Sciences
1505 Marketing
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Persistent URL http://hdl.handle.net/10536/DRO/DU:30093882

Document type: Journal Article
Collections: Faculty of Health
School of Psychology
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