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Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial

Celis-Morales, Carlos, Marsaux, Cyril F.M., Livingstone, Katherine M., Navas-Carretero, Santiago, San-Cristobal, Rodrigo, Fallaize, Rosalind, Macready, Anna L., O'Donovan, Clare, Woolhead, Clara, Forster, Hannah, Kolossa, Silvia, Daniel, Hannelore, Moschonis, George, Mavrogianni, Christina, Manios, Yannis, Surwillo, Agnieszka, Traczyk, Iwona, Drevon, Christian A., Grimaldi, Keith, Bouwman, Jildau, Gibney, Mike J., Walsh, Marianne C., Gibney, Eileen R., Brennan, Lorraine, Lovegrove, Julie A., Martinez, J. Alfredo, Saris, Wim H.M. and Mathers, John C. 2017, Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial, American journal of clinical nutrition, vol. 105, no. 5, pp. 1204-1213, doi: 10.3945/ajcn.116.145680.

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Title Can genetic-based advice help you lose weight? Findings from the Food4Me European randomized controlled trial
Author(s) Celis-Morales, Carlos
Marsaux, Cyril F.M.
Livingstone, Katherine M.ORCID iD for Livingstone, Katherine M. orcid.org/0000-0002-9682-7541
Navas-Carretero, Santiago
San-Cristobal, Rodrigo
Fallaize, Rosalind
Macready, Anna L.
O'Donovan, Clare
Woolhead, Clara
Forster, Hannah
Kolossa, Silvia
Daniel, Hannelore
Moschonis, George
Mavrogianni, Christina
Manios, Yannis
Surwillo, Agnieszka
Traczyk, Iwona
Drevon, Christian A.
Grimaldi, Keith
Bouwman, Jildau
Gibney, Mike J.
Walsh, Marianne C.
Gibney, Eileen R.
Brennan, Lorraine
Lovegrove, Julie A.
Martinez, J. Alfredo
Saris, Wim H.M.
Mathers, John C.
Journal name American journal of clinical nutrition
Volume number 105
Issue number 5
Start page 1204
End page 1213
Total pages 10
Publisher American Society for Nutrition
Place of publication Bethesda, Md.
Publication date 2017-05
ISSN 1938-3207
Keyword(s) FTO
genotype
personalized nutrition
randomized controlled trial
weight
Summary Background: There has been limited evidence about whether genotype-tailored advice provides extra benefits in reducing obesity-related traits compared with the benefits of conventional one-size-fits-all advice.Objective: We determined whether the disclosure of information on fat-mass and obesity-associated (FTO) genotype risk had a greater effect on a reduction of obesity-related traits in risk carriers than in nonrisk carriers across different levels of personalized nutrition.Design: A total of 683 participants (women: 51%; age range: 18-73 y) from the Food4Me randomized controlled trial were included in this analysis. Participants were randomly assigned to 4 intervention arms as follows: level 0, control group; level 1, dietary group; level 2, phenotype group; and level 3, genetic group. FTO (single nucleotide polymorphism rs9939609) was genotyped at baseline in all participants, but only subjects who were randomly assigned to level 3 were informed about their genotypes. Level 3 participants were stratified into risk carriers (AA/AT) and nonrisk carriers (TT) of the FTO gene for analyses. Height, weight, and waist circumference (WC) were self-measured and reported at baseline and months 3 and 6.Results: Changes in adiposity markers were greater in participants who were informed that they carried the FTO risk allele (level 3 AT/AA carriers) than in the nonpersonalized group (level 0) but not in the other personalized groups (level 1 and 2). Mean reductions in weight and WC at month 6 were greater for FTO risk carriers than for noncarriers in the level 3 group [-2.28 kg (95% CI: -3.06, -1.48 kg) compared with -1.99 kg (-2.19, -0.19 kg), respectively (P = 0.037); and -4.34 cm (-5.63, -3.08 cm) compared with -1.99 cm (-4.04, -0.05 cm), respectively, (P = 0.048)].Conclusions: There are greater body weight and WC reductions in risk carriers than in nonrisk carriers of the FTO gene. This trial was registered at clinicaltrials.gov as NCT01530139.
Language eng
DOI 10.3945/ajcn.116.145680
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
11 Medical And Health Sciences
09 Engineering
Socio Economic Objective 0 Not Applicable
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, American Society for Nutrition
Persistent URL http://hdl.handle.net/10536/DRO/DU:30094127

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