Interaction of ketoprofen and frusemide in man

Wa, TC, Lawson, Mary, Jackson, SH, Hitoglou-Makedou, A and Turner, P 1991, Interaction of ketoprofen and frusemide in man, Postgraduate medical journal, vol. 67, no. 789, pp. 655-658, doi: 10.1136/pgmj.67.789.655.

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Title Interaction of ketoprofen and frusemide in man
Author(s) Wa, TC
Lawson, MaryORCID iD for Lawson, Mary orcid.org/0000-0002-9409-6466
Jackson, SH
Hitoglou-Makedou, A
Turner, P
Journal name Postgraduate medical journal
Volume number 67
Issue number 789
Start page 655
End page 658
Total pages 5
Publisher BMJ Publishing Group
Place of publication London, Eng.
Publication date 1991-07
ISSN 0032-5473
Keyword(s) Adult
Diuresis
Double-Blind Method
Drug Interactions
Furosemide
Humans
Ketoprofen
Male
Natriuresis
Renin
Science & Technology
Life Sciences & Biomedicine
Medicine, General & Internal
General & Internal Medicine
RHEUMATOID-ARTHRITIS
RENIN RELEASE
INDOMETHACIN
ACID
Summary The effects of ketoprofen on frusemide-induced diuresis, natriuresis and renin release were studied in 12 healthy male volunteers. Each received frusemide 40 mg once daily with either ketoprofen 100 mg twice daily or placebo for two periods of 5 days separated by a treatment-free period according to a randomized, double-blind, cross-over study design. Ketoprofen significantly reduced frusemide-induced diuresis on Day 1 but not on Day 5 of treatment. The natriuresis induced by frusemide on Day 1 or Day 5 of treatment did not differ significantly whether ketoprofen or placebo was administered, although the mean urinary sodium excretion values were consistently lower following ketoprofen. Ketoprofen did not affect the kaliuretic response to frusemide on Day 1 or Day 5 of treatment. The increase in plasma renin activity after frusemide was inhibited by ketoprofen on both Day 1 and Day 5. These results suggest that ketoprofen reduces the diuresis and renin release induced by frusemide, but that the reduction in diuretic response may become less important after their repeated coadministration.
Language eng
DOI 10.1136/pgmj.67.789.655
Field of Research 119999 Medical and Health Sciences not elsewhere classified
11 Medical And Health Sciences
Socio Economic Objective 929999 Health not elsewhere classified
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ┬ęThe Fellowship of Postgraduate Medicine, 1991
Persistent URL http://hdl.handle.net/10536/DRO/DU:30094156

Document type: Journal Article
Collection: School of Medicine
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