The deterioration in physical function of hemodialysis patients

Sutcliffe, Brianna K., Bennett, Paul N., Fraser, Steve F. and Mohebbi, Mohammadreza 2017, The deterioration in physical function of hemodialysis patients, Hemodialysis international, pp. 1-9, doi: 10.1111/hdi.12570.

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Title The deterioration in physical function of hemodialysis patients
Author(s) Sutcliffe, Brianna K.
Bennett, Paul N.ORCID iD for Bennett, Paul N.
Fraser, Steve F.ORCID iD for Fraser, Steve F.
Mohebbi, MohammadrezaORCID iD for Mohebbi, Mohammadreza
Journal name Hemodialysis international
Start page 1
End page 9
Total pages 9
Publisher Wiley
Place of publication London, Eng.
Publication date 2017-05-05
ISSN 1542-4758
Keyword(s) Hemodialysis
end-stage kidney disease
physical function
Summary INTRODUCTION: Physical function in people on hemodialysis deteriorates significantly, however quantification of the rate of deterioration has not been well established. The aim of this study was to examine the rate of deterioration in objective physical function among end-stage kidney disease patients receiving hemodialysis. METHODS: One hundred and ninety-three participants (mean age 67.5 ±13.2 years, 60.6% males) receiving hemodialysis in Australia. Objective physical function was assessed via the 30-second sit-to-stand and eight-foot timed up-and-go at baseline, 12 and 24 weeks. FINDINGS: We found a decrease in the mean number 30-second sit-to-stands performed from 10.0 (IQR, 4.0 to 13.0); 95% CI (8.0, 11.0) to 8.0 (IQR, 0.0 to 11.0); 95% CI (5.5, 9.0) at 12 weeks to 7.0 (IQR, 0.0 to 11.0); 95% CI (5.5, 9.0) at 24 weeks and a significant overall decreased rate (RR = 0.82; 95% CI, 0.80 to 0.85; P < 0.001). There was a decreased performance in the eight-foot timed up-and-go time from 8.9 seconds (95% CI: 8.1 to 9.7) to 9.0 (95% CI: 8.1 to 9.7) after 12 weeks and further increasing to 9.7 (95% CI: 8.7 to 9.6) seconds after 24 weeks, and overall decreased rate (HR = 0.56; 95% CI, 0.39 to 0.80; P = 0.001) between baseline and week 24. DISCUSSION: Physical function significantly decreases on hemodialysis. Exercise programs to address this physical function decline should be included in hemodialysis treatment regimens.
Notes In Press
Language eng
DOI 10.1111/hdi.12570
Field of Research 110602 Exercise Physiology
1103 Clinical Sciences
Socio Economic Objective 920199 Clinical Health (Organs
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, International Society for Hemodialysis
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Document type: Journal Article
Collection: School of Exercise and Nutrition Sciences
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