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Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome

Izzard, Leonard, Dlugolenski, Daniel, Xia, Yingju, McMahon, Meagan, Middleton, Deborah, Tripp, Ralph A. and Stambas, John 2017, Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome, Virus research, vol. 235, pp. 115-120, doi: 10.1016/j.virusres.2017.04.002.

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Title Enhanced immunogenicity following miR-155 incorporation into the influenza A virus genome
Author(s) Izzard, Leonard
Dlugolenski, Daniel
Xia, Yingju
McMahon, Meagan
Middleton, Deborah
Tripp, Ralph A.
Stambas, John
Journal name Virus research
Volume number 235
Start page 115
End page 120
Total pages 6
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-05-02
ISSN 1872-7492
Keyword(s) B cell
Influenza A
RNAi
T cell
Vaccine
miR-155
Summary Influenza A vaccine efficacy in the elderly is generally poor and so identification of novel molecular adjuvants to improve immunogenicity is important to reduce the overall burden of disease. Short non-coding RNAs, known as microRNAs (miRNAs) are known to regulate gene expression and have the potential to influence immune responses. One such miRNA, miR-155, has been shown to modulate T and B cell development and function. We incorporated miR-155 into the influenza A virus (IAV) genome creating a self-adjuvanting 'live vaccine' with the ability to modify immunogenicity. Infection of mice with a recombinant influenza virus encoding miR-155 in the NS gene segment altered epitope-specific expansion of influenza-specific CD8(+) T cells and induced significantly higher levels of neutralising antibody.
Language eng
DOI 10.1016/j.virusres.2017.04.002
Field of Research 110799 Immunology not elsewhere classified
06 Biological Sciences
07 Agricultural And Veterinary Sciences
Socio Economic Objective 970111 Expanding Knowledge in the Medical and Health Sciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution Non-Commercial No-Derivatives licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30095995

Document type: Journal Article
Collections: School of Medicine
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.