You are not logged in.
Openly accessible

Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease

Hare, Dominic J., Cardoso, Bárbara Rita, Raven, Erika P., Double, Kay L., Finkelstein, David I., Szymlek-Gay, Ewa A. and Biggs, Beverley-Ann 2017, Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease, NPJ Parkinson's disease, vol. 3, doi: 10.1038/s41531-016-0004-y.

Attached Files
Name Description MIMEType Size Downloads
szymlek-excessiveearlylife-2017.pdf Published version application/pdf 1.43MB 3

Title Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease
Author(s) Hare, Dominic J.
Cardoso, Bárbara Rita
Raven, Erika P.
Double, Kay L.
Finkelstein, David I.
Szymlek-Gay, Ewa A.ORCID iD for Szymlek-Gay, Ewa A. orcid.org/0000-0002-6533-7945
Biggs, Beverley-Ann
Journal name NPJ Parkinson's disease
Volume number 3
Article ID 1
Total pages 5
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2017
ISSN 2373-8057
Summary Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life iron exposure that predisposes them to age-related iron accumulation in the brain. Combined with genetic factors that limit iron regulatory capacity and/or dopamine metabolism, this may increase the risk of Parkinson’s diseases. We propose to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; (c) integrate it with in vivo brain iron in Parkinson’s disease; and (d) longitudinally examine the relationships between early-life iron exposure and metabolism, brain iron deposition and Parkinson’s disease risk. This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson’s diseases and produce a potential biomarker of Parkinson’s disease risk in preclinical individuals.
Language eng
DOI 10.1038/s41531-016-0004-y
Field of Research 111199 Nutrition and Dietetics not elsewhere classified
Socio Economic Objective 920112 Neurodegenerative Disorders Related to Ageing
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2016, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30097962

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 12 Abstract Views, 4 File Downloads  -  Detailed Statistics
Created: Mon, 17 Jul 2017, 14:50:06 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.