Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease Hare, Dominic J., Cardoso, Bárbara Rita, Raven, Erika P., Double, Kay L., Finkelstein, David I., Szymlek-Gay, Ewa A. and Biggs, Beverley-Ann 2017, Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease, NPJ Parkinson's disease, vol. 3, doi: 10.1038/s41531-016-0004-y. Attached Files Name Description MIMEType Size Downloads szymlek-excessiveearlylife-2017.pdf Published version application/pdf 1.43MB 68 Title Excessive early-life dietary exposure: a potential source of elevated brain iron and a risk factor for Parkinson's disease Author(s) Hare, Dominic J. Cardoso, Bárbara Rita Raven, Erika P. Double, Kay L. Finkelstein, David I. Szymlek-Gay, Ewa A. orcid.org/0000-0002-6533-7945 Biggs, Beverley-Ann Journal name NPJ Parkinson's disease Volume number 3 Article ID 1 Total pages 5 Publisher Nature Publishing Group Place of publication London, Eng. Publication date 2017 ISSN 2373-8057 Summary Iron accumulates gradually in the ageing brain. In Parkinson’s disease, iron deposition within the substantia nigra is further increased, contributing to a heightened pro-oxidant environment in dopaminergic neurons. We hypothesise that individuals in high-income countries, where cereals and infant formulae have historically been fortified with iron, experience increased early-life iron exposure that predisposes them to age-related iron accumulation in the brain. Combined with genetic factors that limit iron regulatory capacity and/or dopamine metabolism, this may increase the risk of Parkinson’s diseases. We propose to (a) validate a retrospective biomarker of iron exposure in children; (b) translate this biomarker to adults; (c) integrate it with in vivo brain iron in Parkinson’s disease; and (d) longitudinally examine the relationships between early-life iron exposure and metabolism, brain iron deposition and Parkinson’s disease risk. This approach will provide empirical evidence to support therapeutically addressing brain iron deposition in Parkinson’s diseases and produce a potential biomarker of Parkinson’s disease risk in preclinical individuals. Language eng DOI 10.1038/s41531-016-0004-y Field of Research 111199 Nutrition and Dietetics not elsewhere classified Socio Economic Objective 920112 Neurodegenerative Disorders Related to Ageing HERDC Research category C1 Refereed article in a scholarly journal ERA Research output type C Journal article Copyright notice ©2016, The Authors Free to Read? Yes Use Rights Persistent URL http://hdl.handle.net/10536/DRO/DU:30097962 Document type: Journal Article Collections: Faculty of Health School of Exercise and Nutrition Sciences Open Access Collection Related Links Link Description Connect to published version Go to link with your DU access privileges     Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved. Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au. Versions Version Filter Type Mon, 17 Jul 2017, 14:48:58 EST Mon, 17 Jul 2017, 14:50:06 EST Tue, 18 Jul 2017, 05:02:38 EST Thu, 11 Jan 2018, 05:01:28 EST Tue, 16 Jan 2018, 14:28:21 EST Tue, 16 Jan 2018, 14:31:07 EST Mon, 22 Jan 2018, 11:34:30 EST Fri, 07 Sep 2018, 17:57:03 EST Sat, 25 Jan 2020, 01:30:18 EST Sat, 30 May 2020, 02:31:13 EST Filtered Full Citation counts:   Cited 10 times in TR Web of Science Cited 8 times in Scopus Search Google Scholar Access Statistics: 250 Abstract Views, 69 File Downloads  -  Detailed Statistics Created: Mon, 17 Jul 2017, 14:50:06 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.