You are not logged in.
Openly accessible

Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3

Alexandersen, Soren, Nelson, Tiffanie M., Hodge, Jason and Druce, Julian 2017, Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3, Scientific reports, vol. 7, pp. 1-12, doi: 10.1038/s41598-017-04145-2.

Attached Files
Name Description MIMEType Size Downloads
alexandersen-evolutionaryand-2017.pdf Published version application/pdf 1.26MB 6

Title Evolutionary and network analysis of virus sequences from infants infected with an Australian recombinant strain of human parechovirus type 3
Author(s) Alexandersen, SorenORCID iD for Alexandersen, Soren orcid.org/0000-0002-5039-3178
Nelson, Tiffanie M.ORCID iD for Nelson, Tiffanie M. orcid.org/0000-0002-5341-312X
Hodge, Jason
Druce, Julian
Journal name Scientific reports
Volume number 7
Article ID 3861
Start page 1
End page 12
Total pages 12
Publisher Nature Publishing Company
Place of publication London, Eng.
Publication date 2017-06
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
EPIDEMIC MYALGIA
LJUNGAN VIRUS
IDENTIFICATION
ENTEROVIRUS
ECHOVIRUS-22
CHILDREN
PICORNAVIRUS
TRANSMISSION
REPLICATION
DIVERSITY
Summary We present the near complete virus genome sequences with phylogenetic and network analyses of potential transmission networks of a total of 18 Australian cases of human parechovirus type 3 (HPeV3) infection in infants in the period from 2012–2015. Overall the results support our previous finding that the Australian outbreak strain/lineage is a result of a major recombination event that took place between March 2012 and November 2013 followed by further virus evolution and possibly recombination. While the nonstructural coding region of unknown provenance appears to evolve significantly both at the nucleotide and amino acid level, the capsid encoding region derived from the Yamagata 2011 lineage of HPeV3 appears to be very stable, particularly at the amino acid level. The phylogenetic and network analyses performed support a temporal evolution from the first Australian recombinant virus sequence from November 2013 to March/April 2014, onto the 2015 outbreak. The 2015 outbreak samples fall into two separate clusters with a possible common ancestor between March/April 2014 and September 2015, with each cluster further evolving in the period from September to November/December 2015.
Language eng
DOI 10.1038/s41598-017-04145-2
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30098032

Document type: Journal Article
Collections: Faculty of Health
School of Medicine
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 1 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 39 Abstract Views, 7 File Downloads  -  Detailed Statistics
Created: Tue, 18 Jul 2017, 16:26:47 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.