The relationship between weight change and daytime sleepiness: the Sleep Heart Health Study

Ng, Winda Liviya, Orellana, Liliana, Shaw, JE, Wong, Evelyn and Peeters, Anna 2017, The relationship between weight change and daytime sleepiness: the Sleep Heart Health Study, Sleep medicine, vol. 36, pp. 109-118, doi: 10.1016/j.sleep.2017.05.004.

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Title The relationship between weight change and daytime sleepiness: the Sleep Heart Health Study
Author(s) Ng, Winda Liviya
Orellana, LilianaORCID iD for Orellana, Liliana
Shaw, JE
Wong, EvelynORCID iD for Wong, Evelyn
Peeters, Anna
Journal name Sleep medicine
Volume number 36
Start page 109
End page 118
Total pages 10
Publisher Elsevier
Place of publication Amsterdam, The Netherlands
Publication date 2017-08
ISSN 1389-9457
Keyword(s) obesity
weight change
daytime sleepiness
causal inference
causal mediation
obstructive sleep apnoea
Science & Technology
Life Sciences & Biomedicine
Clinical Neurology
Neurosciences & Neurology
Summary OBJECTIVE: Through a causal framework, we aim to assess the association between weight change and daytime sleepiness, and the role of obstructive sleep apnoea (OSA) in this relationship. METHODS: From the Sleep Heart Health Study, we selected individuals who were: (1) 40-64 years old, with (2) body mass index (BMI) ≥18.5 kg/m(2), (3) no history of stroke, treatment for OSA, and tracheostomy at baseline. We used multiple linear regression to assess the relationship between five-year weight change and daytime sleepiness (assessed through Epworth Sleepiness Scale (ESS)) at five years, adjusting for daytime sleepiness, demographics, diabetes, subjective sleep duration, sleep disturbance, smoking status, weight, and use of antidepressants and benzodiazepines at baseline, in those with complete data (N = 1468). We further assessed the potential mediating role of OSA in this relationship. RESULTS: At baseline, the study participants were on average 55 years old, 46% males, with mean BMI 28 kg/m(2); and 25% had ESS>10. ESS at five years worsened by 0.36 units (95% confidence interval (CI) 0.12-0.61, p = 0.004) with every 10-kg weight gain. When stratified by sex, this relationship was only found in women (0.55, 95% CI 0.25-0.86, p < 0.001; p-interaction = 0.02). Approximately one-fifth of the relationship between weight change and daytime sleepiness was mediated by severity of OSA at five years. CONCLUSION: Weight gain has a detrimental effect on daytime sleepiness, mostly through pathways other than OSA. This study provides further evidence and understanding of the relationship between obesity and excessive daytime sleepiness.
Language eng
DOI 10.1016/j.sleep.2017.05.004
Field of Research 111799 Public Health and Health Services not elsewhere classified
1103 Clinical Sciences
1701 Psychology
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Elsevier
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Document type: Journal Article
Collections: Faculty of Health
School of Health and Social Development
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