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Predictive value of UGT1A1*28 polymorphism in irinotecan-based chemotherapy

Liu, Xing-Han, Lu, Jun, Duan, Wei, Dai, Zhi-Ming, Wang, Meng, Lin, Shuai, Yang, Peng-Tao, Tian, Tian, Liu, Kang, Zhu, Yu-Yao, Zheng, Yi, Sheng, Qian-Wen and Dai, Zhi-Jun 2017, Predictive value of UGT1A1*28 polymorphism in irinotecan-based chemotherapy, Journal of cancer, vol. 8, no. 4, pp. 691-703, doi: 10.7150/jca.17210.

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Title Predictive value of UGT1A1*28 polymorphism in irinotecan-based chemotherapy
Author(s) Liu, Xing-Han
Lu, Jun
Duan, WeiORCID iD for Duan, Wei orcid.org/0000-0001-5782-9184
Dai, Zhi-Ming
Wang, Meng
Lin, Shuai
Yang, Peng-Tao
Tian, Tian
Liu, Kang
Zhu, Yu-Yao
Zheng, Yi
Sheng, Qian-Wen
Dai, Zhi-Jun
Journal name Journal of cancer
Volume number 8
Issue number 4
Start page 691
End page 703
Total pages 13
Publisher Ivyspring International Publisher
Place of publication Wyoming, N.S.W.
Publication date 2017
ISSN 1837-9664
Keyword(s) UGT1A1*28
Diarrhea
Neutropenia
Response
Science & Technology
Life Sciences & Biomedicine
Oncology
Summary The UGT1A1*28 polymorphism was suggested to be significantly connected with irinotecan-induced toxicity and response to chemotherapy. However, the results of previous studies are controversial. Hence we carried out a meta-analysis to investigate the effect of UGT1A1*28 polymorphism on severe diarrhea, neutropenia, and response of patients who had undergone irinotecan-based chemotherapy. The PubMed, Web of Science, Wanfang, and CNKI databases were searched for clinical trials assessing the association of UGT1A1*28 polymorphism with severe diarrhea, neutropenia, and response to irinotecan-based chemotherapy. The combined odds ratios (ORs) and 95% confidence intervals (CIs) were used to evaluate the relationship under a fixed- or random-effects model. Fifty-eight studies including 6087 patients with cancer were included. Our results showed that patients carrying the TA6/7 and TA7/7 genotypes had a greater prevalence of diarrhea and neutropenia than those with the TA6/6 genotype (TA6/7+TA7/7 vs. TA6/6: diarrhea, OR = 2.18, 95%CI = 1.68-2.83; neutropenia, OR = 2.15, 95%CI = 1.71-2.70), particularly patients with metastatic colorectal cancer. Stratified analysis showed that Asians with the TA6/7 and TA7/7 genotypes were more likely to have diarrhea and neutropenia, and Caucasians with the TA6/7 and TA7/7 genotypes were more likely to have neutropenia than other groups. However, patients with the TA6/7+TA7/7 genotypes showed a higher response than patients with TA6/6 genotype (OR = 1.20, 95%CI = 1.07-1.34), particularly Caucasians (OR = 1.23, 95%CI = 1.06-1.42) and patients with metastatic colorectal cancer (OR = 1.24, 95%CI = 1.05-1.48). Our data showed that the UGT1A1*28 polymorphism had a significant relationship with toxicity and response to irinotecan-based chemotherapy. This polymorphism may be useful as a monitoring index for cancer patients receiving irinotecan-based chemotherapy.
Language eng
DOI 10.7150/jca.17210
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, Ivyspring International Publisher
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30099146

Document type: Journal Article
Collections: School of Medicine
Open Access Collection
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.