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A comparison of neuroimaging abnormalities in multiple sclerosis, major depression and chronic fatigue syndrome (myalgic encephalomyelitis): is there a common cause?

Morris, Gerwyn, Berk, Michael and Puri, Basant K. 2018, A comparison of neuroimaging abnormalities in multiple sclerosis, major depression and chronic fatigue syndrome (myalgic encephalomyelitis): is there a common cause?, Molecular neurobiology, vol. 55, no. 4, pp. 3592-3609, doi: 10.1007/s12035-017-0598-z.

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Title A comparison of neuroimaging abnormalities in multiple sclerosis, major depression and chronic fatigue syndrome (myalgic encephalomyelitis): is there a common cause?
Author(s) Morris, Gerwyn
Berk, MichaelORCID iD for Berk, Michael orcid.org/0000-0002-5554-6946
Puri, Basant K.
Journal name Molecular neurobiology
Volume number 55
Issue number 4
Start page 3592
End page 3609
Total pages 18
Publisher Springer
Place of publication Cham, Switzerland
Publication date 2018-04
ISSN 1559-1182
Keyword(s) Chronic fatigue syndrome
Depression
Inflammation
Multiple sclerosis
Neuroimaging
Science & Technology
Life Sciences & Biomedicine
Neurosciences
Neurosciences & Neurology
STATE FUNCTIONAL CONNECTIVITY
APPEARING WHITE-MATTER
CEREBRAL-BLOOD-FLOW
VOXEL-BASED MORPHOMETRY
N-ACETYLASPARTATE CONCENTRATION
TREATMENT-RESISTANT DEPRESSION
COGNITIVELY IMPAIRED PATIENTS
POSITRON-EMISSION-TOMOGRAPHY
CLINICALLY ISOLATED SYNDROME
LATE-LIFE DEPRESSION
Summary There is copious evidence of abnormalities in resting-state functional network connectivity states, grey and white matter pathology and impaired cerebral perfusion in patients afforded a diagnosis of multiple sclerosis, major depression or chronic fatigue syndrome (CFS) (myalgic encephalomyelitis). Systemic inflammation may well be a major element explaining such findings. Inter-patient and inter-illness variations in neuroimaging findings may arise at least in part from regional genetic, epigenetic and environmental variations in the functions of microglia and astrocytes. Regional differences in neuronal resistance to oxidative and inflammatory insults and in the performance of antioxidant defences in the central nervous system may also play a role. Importantly, replicated experimental findings suggest that the use of high-resolution SPECT imaging may have the capacity to differentiate patients afforded a diagnosis of CFS from those with a diagnosis of depression. Further research involving this form of neuroimaging appears warranted in an attempt to overcome the problem of aetiologically heterogeneous cohorts which probably explain conflicting findings produced by investigative teams active in this field. However, the ionising radiation and relative lack of sensitivity involved probably preclude its use as a routine diagnostic tool.
Language eng
DOI 10.1007/s12035-017-0598-z
Field of Research 110999 Neurosciences not elsewhere classified
110319 Psychiatry (incl Psychotherapy)
1109 Neurosciences
1702 Cognitive Science
Socio Economic Objective 920410 Mental Health
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30099193

Document type: Journal Article
Collections: Faculty of Health
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.