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Metal ion-loaded nanofibre matrices for calcification inhibition in polyurethane implants

Singh, Charanpreet and Wang, Xungai 2017, Metal ion-loaded nanofibre matrices for calcification inhibition in polyurethane implants, Journal of functional biomaterials, vol. 8, no. 3, pp. 1-16, doi: 10.3390/jfb8030022.

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Title Metal ion-loaded nanofibre matrices for calcification inhibition in polyurethane implants
Author(s) Singh, Charanpreet
Wang, XungaiORCID iD for Wang, Xungai orcid.org/0000-0002-3549-6769
Journal name Journal of functional biomaterials
Volume number 8
Issue number 3
Article ID 22
Start page 1
End page 16
Total pages 16
Publisher MDPI AG
Place of publication Basel, Switzerland
Publication date 2017-09
ISSN 2079-4983
Keyword(s) calcification
magnesium
metal ion
Von Kossa method
Alizarin red S staining
anti-calcification
nanofibre matrix
hydroxyapatite
Summary Pathologic calcification leads to structural deterioration of implant materials via stiffening, stress cracking, and other structural disintegration mechanisms, and the effect can be critical for implants intended for long-term or permanent implantation. This study demonstrates the potential of using specific metal ions (MI)s for inhibiting pathological calcification in polyurethane (PU) implants. The hypothesis of using MIs as anti-calcification agents was based on the natural calcium-antagonist role of Mg2+ ions in human body, and the anti-calcification effect of Fe3+ ions in bio-prosthetic heart valves has previously been confirmed. In vitro calcification results indicated that a protective covering mesh of MI-doped PU can prevent calcification by preventing hydroxyapatite crystal growth. However, microstructure and mechanical characterisation revealed oxidative degradation effects from Fe3+ ions on the mechanical properties of the PU matrix. Therefore, from both a mechanical and anti-calcification effects point of view, Mg2+ ions are more promising candidates than Fe3+ ions. The in vitro MI release experiments demonstrated that PU microphase separation and the structural design of PU-MI matrices were important determinants of release kinetics. Increased phase separation in doped PU assisted in consistent long-term release of dissolved MIs from both hard and soft segments of the PU. The use of a composite-sandwich mesh design prevented an initial burst release which improved the late (>20 days) release rate of MIs from the matrix.
Language eng
DOI 10.3390/jfb8030022
Field of Research 099999 Engineering not elsewhere classified
Socio Economic Objective 970110 Expanding Knowledge in Technology
HERDC Research category C1 Refereed article in a scholarly journal
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30099590

Document type: Journal Article
Collections: Institute for Frontier Materials
Open Access Collection
GTP Research
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.