A view on beta cell transplantation in diabetes

Pipeleers, Daniel, Keymeulen, Bart, Chatenoud, Lucienne, Hendrieckx, Christel, Ling, Zhidong, Mathieu, Chantal, Roep, Bart and Ysebaert, Dirk 2002, A view on beta cell transplantation in diabetes, in ANNALS of the New York Academy of Sciences, Wiley-Blackwell Publishing, Malden, Mass., pp. 69-76, doi: 10.1111/j.1749-6632.2002.tb02948.x.

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Title A view on beta cell transplantation in diabetes
Author(s) Pipeleers, Daniel
Keymeulen, Bart
Chatenoud, Lucienne
Hendrieckx, ChristelORCID iD for Hendrieckx, Christel orcid.org/0000-0002-0075-828X
Ling, Zhidong
Mathieu, Chantal
Roep, Bart
Ysebaert, Dirk
Conference name Immunology of Diabetes Society IDS. International Meeting (5th : 2002)
Conference location Unknown
Conference dates Apr. 2002
Title of proceedings ANNALS of the New York Academy of Sciences
Publication date 2002
Start page 69
End page 76
Total pages 9
Publisher Wiley-Blackwell Publishing
Place of publication Malden, Mass.
Keyword(s) Animals
Antilymphocyte Serum
Cell Culture Techniques
Diabetes Mellitus, Type 1
Humans
Immunosuppression
Islets of Langerhans
Islets of Langerhans Transplantation
Transplantation Tolerance
Summary Organ donors also offer a source of insulin-producing tissue that might be used for the treatment of diabetes. Clinical protocols for transplantation of this tissue aim for the prevention of chronic diabetes complications without introducing new serious side effects. Pancreas and islet cell transplantation are discussed in this perspective. The future of islet cell implants looks favorable but depends on finding ways to induce immune tolerance to the donor beta cells. Clinical trials can take advantage of relevant progress in animal models. In a limited study, recipient treatment with antilymphocyte antibodies and culture of donor cell preparations appeared useful to induce a state of operational immune tolerance in type 1 diabetic patients, as indirectly judged by graft survival and by analysis of auto- and alloreactivities in recipients. Use of cultured beta cell preparations also allows donor cell recruitment from suboptimal donor organs and increases the degree of standardization and quality control of islet cell grafts. The future of these grafts will depend on the development of techniques for the neogenesis of beta cells.
Notes Proceedings of this International Meeting was in the form of a journal article published in the ANNALS of the New York Academy of Sciences
ISSN 0077-8923
Language eng
DOI 10.1111/j.1749-6632.2002.tb02948.x
Field of Research MD Multidisciplinary
HERDC Research category EN.1 Other conference paper
Copyright notice ©2002, New York Academy of Sciences
Persistent URL http://hdl.handle.net/10536/DRO/DU:30099695

Document type: Conference Paper
Collections: Faculty of Health
School of Psychology
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