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Facile control over the supramolecular ordering of self-assembled peptide scaffolds by simultaneous assembly with a polysacharride

Li, Rui, Boyd-Moss, Mitchell, Long, Benjamin, Martel, Anne, Parnell, Andrew, Dennison, Andrew J. C., Barrow, Colin J., Nisbet, David R. and Williams, Richard J. 2017, Facile control over the supramolecular ordering of self-assembled peptide scaffolds by simultaneous assembly with a polysacharride, Scientific reports, vol. 7, no. 1, pp. 1-8, doi: 10.1038/s41598-017-04643-3.

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Title Facile control over the supramolecular ordering of self-assembled peptide scaffolds by simultaneous assembly with a polysacharride
Author(s) Li, Rui
Boyd-Moss, Mitchell
Long, Benjamin
Martel, Anne
Parnell, Andrew
Dennison, Andrew J. C.
Barrow, Colin J.ORCID iD for Barrow, Colin J. orcid.org/0000-0002-2153-7267
Nisbet, David R.
Williams, Richard J.
Journal name Scientific reports
Volume number 7
Issue number 1
Article ID 4797
Start page 1
End page 8
Total pages 8
Publisher Nature Publishing Group
Place of publication London, Eng.
Publication date 2017-07-06
ISSN 2045-2322
Keyword(s) Science & Technology
Multidisciplinary Sciences
Science & Technology - Other Topics
CONTROLLED-RELEASE
SMALL MOLECULES
BROWN-ALGAE
HYDROGEL
FUCOIDAN
POLYELECTROLYTE
BIOMATERIALS
PROTEINS
CELLS
Summary Enabling control over macromolecular ordering and the spatial distribution of structures formed via the mechanisms of molecular self-assembly is a challenge that could yield a range of new functional materials. In particular, using the self-assembly of minimalist peptides, to drive the incorporation of large complex molecules will allow a functionalization strategy for the next generation of biomaterial engineering. Here, for the first time, we show that co-assembly with increasing concentrations of a highly charged polysaccharide, fucoidan, the microscale ordering of Fmoc-FRGDF peptide fibrils and subsequent mechanical properties of the resultant hydrogel can be easily and effectively manipulated without disruption to the nanofibrillar structure of the assembly.
Language eng
DOI 10.1038/s41598-017-04643-3
Field of Research 030699 Physical Chemistry not elsewhere classified
030199 Analytical Chemistry not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30099766

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.