Development of obesity and insulin resistance in the Israeli sand rat (Psammomys obesus). Does leptin play a role?

Collier, G. R., De Silva, A., Sanigorski, A., Walder, K., Yamamoto, A. and Zimmet, P. 1997, Development of obesity and insulin resistance in the Israeli sand rat (Psammomys obesus). Does leptin play a role?, Annals of the New York Academy of Sciences, vol. 827, pp. 50-63, doi: 10.1111/j.1749-6632.1997.tb51821.x.

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Title Development of obesity and insulin resistance in the Israeli sand rat (Psammomys obesus). Does leptin play a role?
Author(s) Collier, G. R.
De Silva, A.
Sanigorski, A.
Walder, K.ORCID iD for Walder, K. orcid.org/0000-0002-6758-4763
Yamamoto, A.
Zimmet, P.
Journal name Annals of the New York Academy of Sciences
Volume number 827
Start page 50
End page 63
Total pages 14
Publisher Wiley-Blackwell
Place of publication Chichester, Eng.
Publication date 1997-09-20
ISSN 0077-8923
Keyword(s) Animals
Disease Models, Animal
Gerbillinae
Humans
Insulin Resistance
Leptin
Mice
Mutation
Obesity
Proteins
Rats
Summary The Israeli Sand Rat (Psammomys obesus) is an excellent polygenic model for the study of obesity and diabetes. The metabolic characteristics and the heterogeneous development of these defects, including elevated leptin levels, mimic those found in susceptible human populations. Interestingly, only animals that develop metabolic abnormalities demonstrate hyperleptinemia and, in these animals, leptin administration at the same dose that is effective in ob/ob mice is ineffective in reducing food intake or body weight. Perhaps leptin resistance needs to develop in Israeli Sand Rats to allow the development of obesity and, in fact, leptin resistance may be the "thrifty gene" that predisposes individuals to the development of obesity and subsequent metabolic abnormalities. However, there remain many unanswered questions about the physiological actions of leptin. The widespread tissue location of receptors and the actions of leptin independent of food intake highlight the need for further research aimed at determining the major physiological action of this newly discovered and exciting hormone.
Language eng
DOI 10.1111/j.1749-6632.1997.tb51821.x
Field of Research MD Multidisciplinary
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©[1997, Wiley]
Persistent URL http://hdl.handle.net/10536/DRO/DU:30100820

Document type: Journal Article
Collection: School of Medicine
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