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Exercise and glycemic control: focus on redox homeostasis and redox-sensitive protein signaling

Parker, Lewan, Shaw, Christopher S, Stepto, Nigel K and Levinger, Itamar 2017, Exercise and glycemic control: focus on redox homeostasis and redox-sensitive protein signaling, Frontiers in endocrinology, vol. 8, pp. 1-22, doi: 10.3389/fendo.2017.00087.

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Title Exercise and glycemic control: focus on redox homeostasis and redox-sensitive protein signaling
Author(s) Parker, Lewan
Shaw, Christopher SORCID iD for Shaw, Christopher S orcid.org/0000-0003-1499-0220
Stepto, Nigel K
Levinger, Itamar
Journal name Frontiers in endocrinology
Volume number 8
Article ID 87
Start page 1
End page 22
Total pages 22
Publisher Frontiers Media
Place of publication Lausanne, Switzerland
Publication date 2017-05
ISSN 1664-2392
Keyword(s) exercise
insulin signaling
stress kinase
glycemic control
oxidative stress
redox
Summary Physical inactivity, excess energy consumption, and obesity are associated with elevated systemic oxidative stress and the sustained activation of redox-sensitive stress-activated protein kinase (SAPK) and mitogen-activated protein kinase signaling pathways. Sustained SAPK activation leads to aberrant insulin signaling, impaired glycemic control, and the development and progression of cardiometabolic disease. Paradoxically, acute exercise transiently increases oxidative stress and SAPK signaling, yet postexercise glycemic control and skeletal muscle function are enhanced. Furthermore, regular exercise leads to the upregulation of antioxidant defense, which likely assists in the mitigation of chronic oxidative stress-associated disease. In this review, we explore the complex spatiotemporal interplay between exercise, oxidative stress, and glycemic control, and highlight exercise-induced reactive oxygen species and redox-sensitive protein signaling as important regulators of glucose homeostasis.
Language eng
DOI 10.3389/fendo.2017.00087
Field of Research 110699 Human Movement and Sports Science not elsewhere classified
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Parker, Shaw, Stepto and Levinger
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30101607

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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.