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Toward hypoxia-selective rhenium and technetium tricarbonyl complexes

North, Andrea J., Hayne, David J., Schieber, Christine, Price, Katherine, White, Anthony R., Crouch, Peter J., Rigopoulos, Angela, O'Keefe, Graeme J., Tochon-Danguy, Henri, Scott, Andrew M., White, Jonathan M., Ackermann, Uwe and Donnelly, Paul S. 2015, Toward hypoxia-selective rhenium and technetium tricarbonyl complexes, Inorganic chemistry, vol. 54, no. 19, pp. 9594-9610, doi: 10.1021/acs.inorgchem.5b01691.

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Title Toward hypoxia-selective rhenium and technetium tricarbonyl complexes
Author(s) North, Andrea J.
Hayne, David J.ORCID iD for Hayne, David J. orcid.org/0000-0003-2756-9427
Schieber, Christine
Price, Katherine
White, Anthony R.
Crouch, Peter J.
Rigopoulos, Angela
O'Keefe, Graeme J.
Tochon-Danguy, Henri
Scott, Andrew M.
White, Jonathan M.
Ackermann, Uwe
Donnelly, Paul S.
Journal name Inorganic chemistry
Volume number 54
Issue number 19
Start page 9594
End page 9610
Total pages 17
Publisher American Chemical Society
Place of publication Washington, D.C.
Publication date 2015-10-05
ISSN 1520-510X
Keyword(s) Animals
Cell Line, Tumor
Diagnostic Imaging
Electrochemical Techniques
HeLa Cells
Humans
Hypoxia
Ligands
Luminescence
Mice
Mice, Inbred BALB C
Mice, Nude
Microscopy, Fluorescence
Models, Molecular
Molecular Structure
Organometallic Compounds
Rhenium
Technetium
Tissue Distribution
Summary With the aim of preparing hypoxia-selective imaging and therapeutic agents, technetium(I) and rhenium(I) tricarbonyl complexes with pyridylhydrazone, dipyridylamine, and pyridylaminocarboxylate ligands containing nitrobenzyl or nitroimidazole functional groups have been prepared. The rhenium tricarbonyl complexes were synthesized with short reaction times using microwave irradiation. Rhenium tricarbonyl complexes with deprotonated p-nitrophenyl pyridylhydrazone ligands are luminescent, and this has been used to track their uptake in HeLa cells using confocal fluorescent microscopy. Selected rhenium tricarbonyl complexes displayed higher uptake in hypoxic cells when compared to normoxic cells. A (99m)Tc tricarbonyl complex with a dipyridylamine ligand bearing a nitroimidazole functional group is stable in human serum and was shown to localize in a human renal cell carcinoma (RCC; SK-RC-52) tumor in a mouse.
Language eng
DOI 10.1021/acs.inorgchem.5b01691
Field of Research 0302 Inorganic Chemistry
0904 Chemical Engineering
0399 Other Chemical Sciences
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2015, American Chemical Society
Free to Read? Yes
Use Rights http://pubs.acs.org/page/policy/authorchoice_termsofuse.html
Persistent URL http://hdl.handle.net/10536/DRO/DU:30101624

Document type: Journal Article
Collections: School of Life and Environmental Sciences
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.