Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor

Valant, Celine, Aurelio, Luigi, Devine, Shane M, Ashton, Trent D, White, Jonathan M, Sexton, Patrick M, Christopoulos, Arthur and Scammells, Peter J 2012, Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor, Journal of medicinal chemistry, vol. 55, no. 5, pp. 2367-2375, doi: 10.1021/jm201600e.

Attached Files
Name Description MIMEType Size Downloads

Title Synthesis and characterization of novel 2-amino-3-benzoylthiophene derivatives as biased allosteric agonists and modulators of the adenosine A(1) receptor
Author(s) Valant, Celine
Aurelio, Luigi
Devine, Shane M
Ashton, Trent DORCID iD for Ashton, Trent D orcid.org/0000-0002-6707-6064
White, Jonathan M
Sexton, Patrick M
Christopoulos, Arthur
Scammells, Peter J
Journal name Journal of medicinal chemistry
Volume number 55
Issue number 5
Start page 2367
End page 2375
Total pages 9
Publisher American Chemical Society
Place of publication Easton, Pa.
Publication date 2012-03-08
ISSN 0022-2623
1520-4804
Keyword(s) Adenosine A1 Receptor Agonists
Allosteric Regulation
Animals
CHO Cells
Cricetinae
Cricetulus
Cyclic AMP
Mitogen-Activated Protein Kinase 1
Mitogen-Activated Protein Kinase 3
Phosphorylation
Receptor, Adenosine A1
Signal Transduction
Structure-Activity Relationship
Thiophenes
Language eng
DOI 10.1021/jm201600e
Field of Research 0304 Medicinal And Biomolecular Chemistry
1115 Pharmacology And Pharmaceutical Sciences
0305 Organic Chemistry
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2012, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30101778

Document type: Journal Article
Collection: School of Life and Environmental Sciences
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 27 times in TR Web of Science
Scopus Citation Count Cited 29 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 54 Abstract Views, 2 File Downloads  -  Detailed Statistics
Created: Fri, 04 Aug 2017, 12:07:20 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.