Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness

Bland, Nicholas D, Wang, Cuihua, Tallman, Craig, Gustafson, Alden E, Wang, Zhouxi, Ashton, Trent D, Ochiana, Stefan O, McAllister, Gregory, Cotter, Kristina, Fang, Anna P, Gechijian, Lara, Garceau, Norman, Gangurde, Rajiv, Ortenberg, Ron, Ondrechen, Mary Jo, Campbell, Robert K and Pollastri, Michael P 2011, Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness, Journal of medicinal chemistry, vol. 54, no. 23, pp. 8188-8194, doi: 10.1021/jm201148s.

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Title Pharmacological validation of Trypanosoma brucei phosphodiesterases B1 and B2 as druggable targets for African sleeping sickness
Author(s) Bland, Nicholas D
Wang, Cuihua
Tallman, Craig
Gustafson, Alden E
Wang, Zhouxi
Ashton, Trent DORCID iD for Ashton, Trent D orcid.org/0000-0002-6707-6064
Ochiana, Stefan O
McAllister, Gregory
Cotter, Kristina
Fang, Anna P
Gechijian, Lara
Garceau, Norman
Gangurde, Rajiv
Ortenberg, Ron
Ondrechen, Mary Jo
Campbell, Robert K
Pollastri, Michael P
Journal name Journal of medicinal chemistry
Volume number 54
Issue number 23
Start page 8188
End page 8194
Total pages 7
Publisher American Chemical Society
Place of publication Easton, Pa.
Publication date 2011-12-08
ISSN 0022-2623
1520-4804
Keyword(s) 3',5'-Cyclic-AMP Phosphodiesterases
Benzamides
Catalytic Domain
Humans
Models, Molecular
Molecular Structure
Pyridines
Recombinant Proteins
Structure-Activity Relationship
Trypanocidal Agents
Trypanosoma brucei brucei
Trypanosomiasis, African
Language eng
DOI 10.1021/jm201148s
Field of Research 0304 Medicinal And Biomolecular Chemistry
1115 Pharmacology And Pharmaceutical Sciences
0305 Organic Chemistry
HERDC Research category C1.1 Refereed article in a scholarly journal
Copyright notice ©2011, American Chemical Society
Persistent URL http://hdl.handle.net/10536/DRO/DU:30101779

Document type: Journal Article
Collection: School of Life and Environmental Sciences
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