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Control mechanism analysis of bone remodelling under mechanical stimuli

Wang, Yanan and Wang, Huaiwen 2015, Control mechanism analysis of bone remodelling under mechanical stimuli, in ICADME 2015 : Proceedings of the 5th International Conference on Advanced Design and Manufacturing Engineering, Atlantis Press, Amsterdam, The Netherlands, pp. 2103-2107, doi: 10.2991/icadme-15.2015.393.

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Title Control mechanism analysis of bone remodelling under mechanical stimuli
Author(s) Wang, YananORCID iD for Wang, Yanan orcid.org/0000-0003-0324-6519
Wang, Huaiwen
Conference name Advanced Design and Manufacturing Engineering Society. Conference (5th : 2015 : Shenzhen, China)
Conference location Shenzhen, China
Conference dates 2015/09/19 - 2015/09/20
Title of proceedings ICADME 2015 : Proceedings of the 5th International Conference on Advanced Design and Manufacturing Engineering
Editor(s) Jiang, Zhengyi
Publication date 2015
Series Advanced Design and Manufacturing Engineering Society Conference
Start page 2103
End page 2107
Total pages 5
Publisher Atlantis Press
Place of publication Amsterdam, The Netherlands
Keyword(s) bone remodelling
control mechanism
mechanical stimuli
Summary In this paper the control mechanism of bone remodelling under mechanical stimuli at cellular level is investigated by means of an extensive parametric study on a theoretical model developed previously. From a perspective of control mechanism, it is found that there are several control mechanisms working simultaneously in bone remodelling which is a complex process. To this purpose, an extensive parametric study has been carried out for investigating model parameter space related to cell differentiation and apoptosis which can describe the fundamental cell lineage behaviors. After analyzing all the combinations of 728 permutations in six model parameters, we have identified a small number of parameter combinations that can lead to physiologically realistic responses which are similar to theoretically idealized physiological responses. The results presented in the work enhanced our understanding on mechanical bone remodelling and the identified control mechanisms can help researchers to develop combined pharmacological-mechanical therapies to treat bone loss diseases such as osteoporosis.
ISBN 978-94-6252-113-1
ISSN 2352-5401
Language eng
DOI 10.2991/icadme-15.2015.393
HERDC Research category E1.1 Full written paper - refereed
ERA Research output type E Conference publication
Copyright notice ©2015, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30102132

Document type: Conference Paper
Collections: School of Engineering
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Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.