Openly accessible

Association of left ventricular ejection fraction with contrast-induced nephropathy and mortality following coronary angiography or intervention in patients with heart failure

Wang, Kun, Li, Hua-long, Bei, Wei-jie, Guo, Xiao-sheng, Chen, Shi-qun, Islam, Sheikh Mohammed Shariful, Chen, Ji-yan, Liu, Yong and Tan, Ning 2017, Association of left ventricular ejection fraction with contrast-induced nephropathy and mortality following coronary angiography or intervention in patients with heart failure, Therapeutics and clinical risk management, vol. 13, pp. 887-895, doi: 10.2147/TCRM.S137654.

Attached Files
Name Description MIMEType Size Downloads
islam-associationofleft-2017.pdf Published version application/pdf 796.29KB 5

Title Association of left ventricular ejection fraction with contrast-induced nephropathy and mortality following coronary angiography or intervention in patients with heart failure
Author(s) Wang, Kun
Li, Hua-long
Bei, Wei-jie
Guo, Xiao-sheng
Chen, Shi-qun
Islam, Sheikh Mohammed SharifulORCID iD for Islam, Sheikh Mohammed Shariful orcid.org/0000-0001-7926-9368
Chen, Ji-yan
Liu, Yong
Tan, Ning
Journal name Therapeutics and clinical risk management
Volume number 13
Start page 887
End page 895
Total pages 9
Publisher Dove Medical Press
Place of publication Macclesfield, Eng.
Publication date 2017-07-19
ISSN 1176-6336
1178-203X
Keyword(s) cardiac catheterization
contrast-induced nephropathy
left ventricular ejection fraction
heart failure
Summary Background: Left ventricular ejection fraction (LVEF) is the most widely used parameter to evaluate the cardiac function in patients with heart failure (HF). However, the association between LVEF and contrast-induced nephropathy (CIN) is still controversial. Therefore, the aim of this study is to evaluate the association of LVEF with CIN and long-term mortality following coronary angiography (CAG) or intervention in patients with HF.

Methods: We analyzed 1,647 patients with HF (New York Heart Association [NYHA] or Killip class >1) undergoing CAG or intervention, including 207 (12.57%) patients with reduced LVEF (HFrEF), 238 (14.45%) with mid-range LVEF (HFmrEF) and 1,202 (72.98%) with preserved LVEF (HFpEF). CIN was defined as an absolute increase of ≥0.5 mg/dL or a relative increase of ≥25% from baseline serum creatinine within 48–72 h after contrast medium exposure. Multivariable logistic regression and Cox proportional hazards regression analyses were performed to identify the association between LVEF, CIN and long-term mortality, respectively.

Results: Overall, 225 patients (13.7%) developed CIN. Individuals with lower LVEF were more likely to develop CIN (HFrEF, HFmrEF and HFpEF: 18.4%, 21.8% and 11.2%, respectively; P<0.001), but without a significant trend after adjusting for the confounding factors (HFrEF vs HFpEF: odds ratio [OR] =1.01; HFmrEF vs HFpEF: OR =1.31; all P>0.05). However, advanced HF (NYHA class >2 or Killip class >1) was an independent predictor of CIN (adjusted OR =1.54, 95% confidence interval [CI], 1.07–2.22; P=0.019). During the mean follow-up of 2.3 years, reduced LVEF (HFrEF group) was significantly associated with increased mortality (HFrEF vs HFpEF: adjusted hazard ratio =2.88, 95% CI, 1.77–4.69; P<0.001).

Conclusion: In patients with HF undergoing CAG or intervention, not worsened LVEF but advanced HF was associated with an increased risk of CIN. In addition, reduced LVEF was an independent predictor of long-term mortality following cardiac catheterization.
Language eng
DOI 10.2147/TCRM.S137654
Field of Research 1117 Public Health And Health Services
HERDC Research category C1.1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, Wang et al.
Free to Read? Yes
Use Rights Creative Commons Attribution non-commercial licence
Persistent URL http://hdl.handle.net/10536/DRO/DU:30102239

Document type: Journal Article
Collections: School of Exercise and Nutrition Sciences
Open Access Collection
Connect to link resolver
 
Unless expressly stated otherwise, the copyright for items in DRO is owned by the author, with all rights reserved.

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.

Versions
Version Filter Type
Citation counts: TR Web of Science Citation Count  Cited 0 times in TR Web of Science
Scopus Citation Count Cited 0 times in Scopus
Google Scholar Search Google Scholar
Access Statistics: 45 Abstract Views, 7 File Downloads  -  Detailed Statistics
Created: Wed, 16 Aug 2017, 12:52:36 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.