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Advances in closed-loop deep brain stimulation devices

Parastarfeizabadi, Mahboubeh and Kouzani, Abbas Z. 2017, Advances in closed-loop deep brain stimulation devices, Journal of neuroengineering and rehabilitation, vol. 14, pp. 1-20, doi: 10.1186/s12984-017-0295-1.

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Title Advances in closed-loop deep brain stimulation devices
Author(s) Parastarfeizabadi, Mahboubeh
Kouzani, Abbas Z.ORCID iD for Kouzani, Abbas Z.
Journal name Journal of neuroengineering and rehabilitation
Volume number 14
Article ID 79
Start page 1
End page 20
Total pages 20
Publisher BioMed Central
Place of publication London, Eng.
Publication date 2017-08-11
ISSN 1743-0003
Keyword(s) deep rain simulation
closed-loop control
signal conditioning
deep brain simulation
Science & Technology
Life Sciences & Biomedicine
Engineering, Biomedical
Neurosciences & Neurology
Summary BACKGROUND: Millions of patients around the world are affected by neurological and psychiatric disorders. Deep brain stimulation (DBS) is a device-based therapy that could have fewer side-effects and higher efficiencies in drug-resistant patients compared to other therapeutic options such as pharmacological approaches. Thus far, several efforts have been made to incorporate a feedback loop into DBS devices to make them operate in a closed-loop manner.

METHODS: This paper presents a comprehensive investigation into the existing research-based and commercial closed-loop DBS devices. It describes a brief history of closed-loop DBS techniques, biomarkers and algorithms used for closing the feedback loop, components of the current research-based and commercial closed-loop DBS devices, and advancements and challenges in this field of research. This review also includes a comparison of the closed-loop DBS devices and provides the future directions of this area of research.

RESULTS: Although we are in the early stages of the closed-loop DBS approach, there have been fruitful efforts in design and development of closed-loop DBS devices. To date, only one commercial closed-loop DBS device has been manufactured. However, this system does not have an intelligent and patient dependent control algorithm. A closed-loop DBS device requires a control algorithm to learn and optimize the stimulation parameters according to the brain clinical state.

CONCLUSIONS: The promising clinical effects of open-loop DBS have been demonstrated, indicating DBS as a pioneer technology and treatment option to serve neurological patients. However, like other commercial devices, DBS needs to be automated and modernized.
Language eng
DOI 10.1186/s12984-017-0295-1
Field of Research 0903 Biomedical Engineering
1109 Neurosciences
HERDC Research category C1 Refereed article in a scholarly journal
ERA Research output type C Journal article
Copyright notice ©2017, The Authors
Free to Read? Yes
Use Rights Creative Commons Attribution licence
Persistent URL

Document type: Journal Article
Collections: School of Engineering
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Created: Mon, 30 Oct 2017, 17:48:23 EST

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact