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Functionality determination and characterization of an angiogenesis-inhibiting fusion protein

Chakrabarti, Sanjukta 2016, Functionality determination and characterization of an angiogenesis-inhibiting fusion protein, PhD thesis, School of Life and Environmental Sciences, Deakin Univeristy.

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Title Functionality determination and characterization of an angiogenesis-inhibiting fusion protein
Author Chakrabarti, Sanjukta
Institution Deakin Univeristy
School School of Life and Environmental Sciences
Faculty Faculty of Science Engineering and Built Environment
Degree type Research doctorate
Degree name PhD
Thesis advisor Barrow, ColinORCID iD for Barrow, Colin orcid.org/0000-0002-2153-7267
Kanwar JagatORCID iD for Kanwar Jagat orcid.org/0000-0003-3728-9568
Date submitted 2016-09
Keyword(s) cancer therapy
angiogenesis
vascular endothelial growth factor (VEGF)
Summary Angiogenesis is a hallmark of cancer and VEGF is the most potent pro-angiogenic factor that stimulates angiogenesis in diseases including cancer, A recombinant anti-VEGF, Fc-fusion protein, VEGFR1(D1-D3)-Fc was developed and characterized. The protein demonstrated strong binding affinity to VEGF and anti-angiogenic functions in cell-based assays and animal model of cancer.
Language eng
Field of Research 111504 Pharmaceutical Sciences
111204 Cancer Therapy (excl Chemotherapy and Radiation Therapy)
111207 Molecular Targets
Socio Economic Objective 920102 Cancer and Related Disorders
Description of original xxxiii, 409 pages : illustrations, tables, graphs, some coloured
Copyright notice ┬ęThe author. All Rights Reserved.
Free to Read? Yes
Persistent URL http://hdl.handle.net/10536/DRO/DU:30102718

Document type: Thesis
Collections: Higher degree theses (full text)
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Created: Fri, 22 Sep 2017, 11:56:17 EST by Asif, Yasmin

Every reasonable effort has been made to ensure that permission has been obtained for items included in DRO. If you believe that your rights have been infringed by this repository, please contact drosupport@deakin.edu.au.