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Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol.

Carland, M, Tan, KJ, White, JM, Stephenson, J, Murray, V, Denny, WA and McFadyen, WD 2005, Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol., Journal of Inorganic Biochemistry, vol. 99, no. 8, pp. 1738-1743, doi: 10.1016/j.jinorgbio.2005.06.003.

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Title Syntheses, crystal structure and cytotoxicity of diamine platinum(II) complexes containing maltol.
Author(s) Carland, M
Tan, KJ
White, JM
Stephenson, J
Murray, V
Denny, WA
McFadyen, WD
Journal name Journal of Inorganic Biochemistry
Volume number 99
Issue number 8
Start page 1738
End page 1743
Total pages 6
Publisher Elsevier
Place of publication United States
Publication date 2005-08
ISSN 0162-0134
Keyword(s) Cell Line, Tumor
Crystallography, X-Ray
Diamines
Humans
Inhibitory Concentration 50
Molecular Structure
Platinum Compounds
Pyrones
Science & Technology
Life Sciences & Biomedicine
Physical Sciences
Biochemistry & Molecular Biology
Chemistry, Inorganic & Nuclear
Chemistry
diamineplatinum(II)
maltolate
synthesis
structure
cytotoxicity
X-RAY
PHENANTHRIDINIUM COMPLEXES
IN-VITRO
DNA
CISPLATIN
DRUGS
Summary The cationic complexes (1,2-diaminoethane)(maltolato)platinum(II) ([Pt(en)(ma)]+) and (1R,2R-1,2-diaminocyclohexane)(maltolato)platinum(II) ([Pt(R,R-DACH)(ma)]+) have been prepared and the structure of [Pt(R,R-DACH)(ma)]NO3 has been determined by single crystal X-ray diffraction. The geometry of the metal in [Pt(R,R-DACH)(ma)]NO3 is essentially square planar and the maltolate ligand has a geometry similar to other chelate complexes involving this ligand. The cytotoxicities of the compounds have been assessed in the human cell lines HeLa and K562 and the IC50 values are approximately 32 microM in HeLa cells and 26 microM in K562 cells. In these cell lines the cytotoxicity of cisplatin is higher than the maltolate complexes by a factor of 2 to 3 whereas the cytotoxicity of carboplatin is lower than the maltolate complexes.
Language eng
DOI 10.1016/j.jinorgbio.2005.06.003
Field of Research 0302 Inorganic Chemistry
Persistent URL http://hdl.handle.net/10536/DRO/DU:30102731

Document type: Journal Article
Collection: Institute for Frontier Materials
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